Comprehensive review of uterine fibroids: developmental origin, pathogenesis, and treatment

Q Yang, M Ciebiera, MV Bariani, M Ali… - Endocrine …, 2022 - academic.oup.com
Uterine fibroids are benign monoclonal neoplasms of the myometrium, representing the
most common tumors in women worldwide. To date, no long-term or noninvasive treatment …

Molecular and cellular insights into the development of uterine fibroids

A Machado-Lopez, C Simón, A Mas - International journal of molecular …, 2021 - mdpi.com
Uterine leiomyomas represent the most common benign gynecologic tumor. These hormone-
dependent smooth-muscle formations occur with an estimated prevalence of~ 70% among …

Integrative genomic and transcriptomic profiling reveals a differential molecular signature in uterine leiomyoma versus leiomyosarcoma

A Machado-Lopez, R Alonso, V Lago… - International journal of …, 2022 - mdpi.com
The absence of standardized molecular profiling to differentiate uterine leiomyosarcomas
versus leiomyomas represents a current diagnostic challenge. In this study, we aimed to …

Unmet medical needs and future perspectives for leiomyosarcoma patients—a position paper from the National LeioMyoSarcoma Foundation (NLMSF) and Sarcoma …

B Kasper, A Achee, K Schuster, R Wilson… - Cancers, 2021 - mdpi.com
Simple Summary In this position paper, we aim to summarize state-of-the-art treatments for
patients with leiomyosarcomas in order to identify knowledge gaps and current unmet …

[HTML][HTML] FTIR Microspectroscopy as a new probe to study human uterine lesions: Characterization of tumor cell lines from uterine smooth muscle cells and evaluation …

A Belloni, V Notarstefano, S Greco, P Pellegrino… - … et Biophysica Acta (BBA …, 2024 - Elsevier
During their life, women are likely to develop uterine diseases, which often compromise their
fertile and perimenopausal age. Besides benign lesions like leiomyomas, several malignant …

What clinical trials are needed for treatment of leiomyosarcoma?

B Kasper, L D'Ambrosio, EJ Davis, M Ingham… - … treatment options in …, 2022 - Springer
Opinion statement Leiomyosarcoma is one of the most common subtypes of soft tissue
sarcomas accounting for approximately 20% of sarcomas. As leiomyosarcoma patients …

Development of uterine leiomyosarcoma during follow-up after caesarean section in a woman with uterine leiomyoma

K Watanabe, T Hayashi, M Katsumata… - Anticancer …, 2021 - ar.iiarjournals.org
Background/Aim: During pregnancy, uterine leiomyomas may cause problems and
treatment typically entails uterine conservation. However, for cases of leiomyomas larger …

Liquid biopsy as a tool for differentiation of leiomyomas and sarcomas of corpus uteri

D Dvorská, H Škovierová, D Braný, E Halašová… - International Journal of …, 2019 - mdpi.com
Utilization of liquid biopsy in the management of cancerous diseases is becoming more
attractive. This method can overcome typical limitations of tissue biopsies, especially …

[HTML][HTML] Potential Markers to Differentiate Uterine Leiomyosarcomas from Leiomyomas

J Guo, J Zheng, J Tong - International Journal of Medical Sciences, 2024 - ncbi.nlm.nih.gov
Uterine leiomyomas (ULM) are the most common benign tumors of the female genitalia,
while uterine leiomyosarcomas (ULMS) are rare. The sarcoma is diffuse growth, prone to …

Genomic alterations in gynecological malignancies: histotype-associated driver mutations, molecular subtyping schemes, and tumorigenic mechanisms

S Mori, O Gotoh, K Kiyotani, SK Low - Journal of Human Genetics, 2021 - nature.com
There are numerous histological subtypes (histotypes) of gynecological malignancies, with
each histotype considered to largely reflect a feature of the “cell of origin,” and to be tightly …