The APOBEC family of single-stranded DNA cytosine deaminases comprises a formidable
arm of the vertebrate innate immune system. Pre-vertebrates express a single APOBEC …

Transposable elements (TEs) are genetic elements with the ability to mobilize and replicate
themselves in a genome. Mammalian genomes are dominated by TEs, which can reach …

Elucidation of mutagenic processes shaping cancer genomes is a fundamental problem
whose solution promises insights into new treatment, diagnostic and prevention strategies …

Reverse transcription and integration are the defining features of the Retroviridae; the
common name “retrovirus” derives from the fact that these viruses use a virally encoded …

APOBEC3B cytosine deaminase activity has recently emerged as a significant mutagenic
factor in human cancer. APOBEC activity is induced in virally infected cells, and APOBEC …

APOBEC mutagenesis, a major driver of cancer evolution, is known for targeting TpC sites in
DNA. Recently, we showed that APOBEC3A (A3A) targets DNA hairpin loops. Here, we …

Breast cancer genomes have revealed a novel form of mutation showers (kataegis) in which
multiple same-strand substitutions at C: G pairs spaced one to several hundred nucleotides …

Host restriction factors are potent, widely expressed intracellular blocks to viral replication
that are an important component of the innate immune response to viral infection. However …

To replicate in their hosts, viruses have to navigate the complexities of the mammalian cell,
co-opting mechanisms of cellular physiology while defeating restriction factors that are …

Mutations are typically perceived as random, independent events. We describe here
nonrandom clustered mutations in yeast and in human cancers. Genome sequencing of …