A comprehensive review and update on the pathogenesis of inflammatory bowel disease
Q Guan - Journal of immunology research, 2019 - Wiley Online Library
Inflammatory bowel disease (IBD) is a chronic and life‐threating inflammatory disease of
gastroenteric tissue characterized by episodes of intestinal inflammation. The pathogenesis …
gastroenteric tissue characterized by episodes of intestinal inflammation. The pathogenesis …
The TNF receptor superfamily in co-stimulating and co-inhibitory responses
Cytokines related to tumor necrosis factor (TNF) provide a communication network essential
for coordinating multiple cell types into an effective host defense system against pathogens …
for coordinating multiple cell types into an effective host defense system against pathogens …
Beyond TNF: TNF superfamily cytokines as targets for the treatment of rheumatic diseases
M Croft, RM Siegel - Nature Reviews Rheumatology, 2017 - nature.com
TNF blockers are highly efficacious at dampening inflammation and reducing symptoms in
rheumatic diseases such as rheumatoid arthritis, psoriatic arthritis and ankylosing …
rheumatic diseases such as rheumatoid arthritis, psoriatic arthritis and ankylosing …
CX3CR1+ mononuclear phagocytes support colitis-associated innate lymphoid cell production of IL-22
Interleukin (IL)-22–producing group 3 innate lymphoid cells (ILC3) promote mucosal healing
and maintain barrier integrity, but how microbial signals are integrated to regulate mucosal …
and maintain barrier integrity, but how microbial signals are integrated to regulate mucosal …
The role of TNF superfamily members in T-cell function and diseases
M Croft - Nature Reviews Immunology, 2009 - nature.com
Interactions that occur between several tumour necrosis factor (TNF)–TNF receptors that are
expressed by T cells and various other immune and non-immune cell types are central to T …
expressed by T cells and various other immune and non-immune cell types are central to T …
Crohn's disease: Th1, Th17 or both? The change of a paradigm: new immunological and genetic insights implicate Th17 cells in the pathogenesis of Crohn's disease
S Brand - Gut, 2009 - gut.bmj.com
Traditionally, Crohn's disease has been associated with a Th1 cytokine profile, while Th2
cytokines are modulators of ulcerative colitis. This concept has been challenged by the …
cytokines are modulators of ulcerative colitis. This concept has been challenged by the …
The TNF–TNFR family of co-signal molecules
T So, N Ishii - Co-signal Molecules in T Cell Activation: Immune …, 2019 - Springer
Costimulatory signals initiated by the interaction between the tumor necrosis factor (TNF)
ligand and cognate TNF receptor (TNFR) superfamilies promote clonal expansion …
ligand and cognate TNF receptor (TNFR) superfamilies promote clonal expansion …
TNF superfamily in inflammatory disease: translating basic insights
M Croft, W Duan, H Choi, SY Eun, S Madireddi… - Trends in …, 2012 - cell.com
The tumor necrosis factor (TNF) and TNF receptor superfamilies (TNFSF and TNFRSF)
consist of approximately 50 membrane and soluble proteins that can modulate cellular …
consist of approximately 50 membrane and soluble proteins that can modulate cellular …
Innate immune recognition of infected apoptotic cells directs TH17 cell differentiation
MB Torchinsky, J Garaude, AP Martin, JM Blander - Nature, 2009 - nature.com
Adaptive immune responses rely on differentiation of CD4 T helper cells into subsets with
distinct effector functions best suited for host defence against the invading pathogen …
distinct effector functions best suited for host defence against the invading pathogen …