The protein kinase, GSK-3, participates in diverse biological processes and is now
recognized a promising drug discovery target in treating multiple pathological conditions …

Dopamine (DA) is one of the major neurotransmitters and participates in a number of
functions such as motor coordination, emotions, memory, reward mechanism …

Abstract Glycogen synthase kinase-3 (GSK-3) is associated with various key biological
processes, including glucose regulation, apoptosis, protein synthesis, cell signaling, cellular …

Neurodegenerative disorders are spreading worldwide and are one of the greatest threats to
public health. There is currently no adequate therapy for these disorders, and therefore there …

Abstract Glycogen Synthase Kinase-3 (GSK3) was originally reported as a key enzyme of
glucose homeostasis through regulation of the rate of glycogen synthesis. It has …

Collapsin response mediator proteins (CRMPs) are a family of ubiquitously expressed,
homologous phosphoproteins best known for coordinating cytoskeletal formation and …

Glycogen synthase kinase-3β (GSK-3β) has emerged as a critical factor in several pathways
involved in hippocampal neuronal maintenance and function. In Huntington's disease (HD) …

Kinases are an intensively studied drug target class in current pharmacological research as
evidenced by the large number of kinase inhibitors being assessed in clinical trials. Kinase …

Huntington's disease is a neurodegenerative disorder caused by a CAG repeat expansion in
exon 1 of the huntingtin gene. Striatal projection neurons are mainly affected, leading to …

Tauopathies are a subclass of neurodegenerative diseases typified by the deposition of
abnormal microtubule-associated tau protein within the cerebral tissue. Alzheimer's disease …