[HTML][HTML] Hallmarks of aging: An expanding universe
Aging is driven by hallmarks fulfilling the following three premises:(1) their age-associated
manifestation,(2) the acceleration of aging by experimentally accentuating them, and (3) the …
manifestation,(2) the acceleration of aging by experimentally accentuating them, and (3) the …
Meta-hallmarks of aging and cancer
Both aging and cancer are characterized by a series of partially overlapping" hallmarks" that
we subject here to a meta-analysis. Several hallmarks of aging (ie, genomic instability …
we subject here to a meta-analysis. Several hallmarks of aging (ie, genomic instability …
[HTML][HTML] Inhibition of fatty acid oxidation enables heart regeneration in adult mice
X Li, F Wu, S Günther, M Looso, C Kuenne, T Zhang… - Nature, 2023 - nature.com
Postnatal maturation of cardiomyocytes is characterized by a metabolic switch from
glycolysis to fatty acid oxidation, chromatin reconfiguration and exit from the cell cycle …
glycolysis to fatty acid oxidation, chromatin reconfiguration and exit from the cell cycle …
Cellular rejuvenation: molecular mechanisms and potential therapeutic interventions for diseases
S Ji, M Xiong, H Chen, Y Liu, L Zhou, Y Hong… - … and Targeted Therapy, 2023 - nature.com
The ageing process is a systemic decline from cellular dysfunction to organ degeneration,
with more predisposition to deteriorated disorders. Rejuvenation refers to giving aged cells …
with more predisposition to deteriorated disorders. Rejuvenation refers to giving aged cells …
The information theory of aging
Abstract Information storage and retrieval is essential for all life. In biology, information is
primarily stored in two distinct ways: the genome, comprising nucleic acids, acts as a …
primarily stored in two distinct ways: the genome, comprising nucleic acids, acts as a …
Multi‐omic rejuvenation of naturally aged tissues by a single cycle of transient reprogramming
D Chondronasiou, D Gill, L Mosteiro, RG Urdinguio… - Aging …, 2022 - Wiley Online Library
The expression of the pluripotency factors OCT4, SOX2, KLF4, and MYC (OSKM) can
convert somatic differentiated cells into pluripotent stem cells in a process known as …
convert somatic differentiated cells into pluripotent stem cells in a process known as …
In vivo partial cellular reprogramming enhances liver plasticity and regeneration
T Hishida, M Yamamoto, Y Hishida-Nozaki, C Shao… - Cell reports, 2022 - cell.com
Mammals have limited regenerative capacity, whereas some vertebrates, like fish and
salamanders, are able to regenerate their organs efficiently. The regeneration in these …
salamanders, are able to regenerate their organs efficiently. The regeneration in these …
Vitamin B12 is a limiting factor for induced cellular plasticity and tissue repair
M Kovatcheva, E Melendez, D Chondronasiou… - Nature …, 2023 - nature.com
Transient reprogramming by the expression of OCT4, SOX2, KLF4 and MYC (OSKM) is a
therapeutic strategy for tissue regeneration and rejuvenation, but little is known about its …
therapeutic strategy for tissue regeneration and rejuvenation, but little is known about its …
In vivo reprogramming leads to premature death linked to hepatic and intestinal failure
The induction of cellular reprogramming via expression of the transcription factors Oct4,
Sox2, Klf4 and c‐Myc (OSKM) can drive dedifferentiation of somatic cells and ameliorate …
Sox2, Klf4 and c‐Myc (OSKM) can drive dedifferentiation of somatic cells and ameliorate …
A single short reprogramming early in life initiates and propagates an epigenetically related mechanism improving fitness and promoting an increased healthy lifespan
Q Alle, E Le Borgne, P Bensadoun, C Lemey… - Aging …, 2022 - Wiley Online Library
Recent advances in cell reprogramming showed that OSKM induction is able to improve cell
physiology in vitro and in vivo. Here, we show that a single short reprogramming induction is …
physiology in vitro and in vivo. Here, we show that a single short reprogramming induction is …