Neurotrophic factors, particularly BDNF (brain-derived neurotrophic factor), have been
associated with depression and antidepressant drug action. A variety of preclinical and …

In the past years, several theories have been advanced to explain the pathogenesis of Major
Depressive Disorder (MDD), a neuropsychiatric disease that causes disability in general …

Ketamine has emerged as a widespread treatment for a variety of psychiatric disorders
when used at sub-anesthetic doses, but the neural mechanisms underlying its acute action …

Using pre-treatment biomarkers to guide patients to the preferred antidepressant medication
treatment could be a promising approach to enhance its current modest response and …

Objective Amygdala− ventrolateral prefrontal cortex (VLPFC) circuitry is disrupted in
pediatric anxiety disorders, yet how selective serotonin reuptake inhibitors (SSRIs) affect this …

Neonatal hypoxia-ischemia (nHI) disrupts hippocampal GABAergic development leading to
memory deficits in mice. Polysialic-acid neural-cell adhesion molecule (PSA-NCAM) …

This manuscript is dedicated to the memory of Bruce S. McEwen, to commemorate the
impact he had on how we understand stress and neuronal plasticity, and the profound …

In mature mammalian brains, the endocannabinoid system (ECS) plays an important role in
the regulation of synaptic plasticity and the functioning of neural networks. Besides, the ECS …

Selective serotonin reuptake inhibitors, such as fluoxetine (Prozac), are commonly
prescribed pharmacotherapies for anxiety. Fluoxetine may be a useful adjunct because it …

Despite common use of antidepressants to treat postpartum depression, little is known about
the impact of antidepressant use on postpartum brain activity. Additionally, although oxytocin …