Blood production depends on rare haematopoietic stem cells (HSCs) and haematopoietic
stem and progenitor cells (HSPCs) that ultimately take up residence in the bone marrow …

The central role of the endothelial microenvironment in orchestrating bone marrow (BM)
homeostasis and hematopoietic support has been confirmed at various developmental …

Cell segmentation and classification are critical tasks in spatial omics data analysis. Here we
introduce CelloType, an end-to-end model designed for cell segmentation and classification …

Myeloproliferative neoplasms are stem cell–driven cancers associated with a large burden
of morbidity and mortality. Most patients present with early-stage disease, but a substantial …

Tissue clearing combined with high-resolution confocal imaging is a cutting-edge approach
for dissecting the three-dimensional (3D) architecture of tissues and deciphering cellular …

The bone is a frequent metastatic site, with changes in the mineralized bone and the bone
marrow milieu that can also prime other sites for metastasis by educating progenitor cells to …

Multiple myeloma is an incurable plasma cell malignancy that evolves over decades through
the selection and malignant transformation of monoclonal plasma cells. The evolution from …

Bone is a multifaceted tissue requiring orchestrated interplays of diverse cells within
specialized microenvironments. Although significant progress has been made in …

Hematopoietic stem cells (HSC) reside within specialized microenvironments that undergo
dynamic changes throughout development and aging to support HSC function. However, the …

Recent years have seen the rapid emergence of spatial transcriptomic (ST) technologies
that provide spatially resolved expression-based descriptions of tissue architecture. These …