Nicotinamide adenine dinucleotide, in its oxidized (NAD+) and reduced (NADH) forms, is a
reduction–oxidation (redox) co-factor and substrate for signalling enzymes that have …

Diabetes, a complex multisystem metabolic disorder characterized by hyperglycemia, leads
to complications that reduce quality of life and increase mortality. Diabetes pathophysiology …

NAD+, the essential metabolite involved in multiple reactions such as the regulation of
cellular metabolism, energy production, DNA repair, mitophagy and autophagy …

The geroscience hypothesis proposes that addressing the biology of aging could directly
prevent the onset or mitigate the severity of multiple chronic diseases. Understanding the …

Worldwide, over 800 million people are affected by kidney disease, yet its pathogenesis
remains elusive, hindering the development of novel therapeutics. In this study, we used …

Damage-associated molecular patterns (DAMPs) are endogenous molecules that are
released from host cells as a result of cell death or damage. The release of DAMPs in …

The understanding of cardiovascular-kidney-metabolic syndrome remains difficult despite
recently performed large scale genome-wide association studies. Here, we identified beta …

Recent research has unveiled an expansive role of NAD+ in cellular energy generation,
redox reactions, and as a substrate or cosubstrate in signaling pathways that regulate health …

Many studies have suggested that the oxidized form of nicotinamide adenine dinucleotide
(NAD+) is involved in an extensive spectrum of human pathologies, including …

Vitamin A (VA, retinol) and its metabolites (commonly called retinoids) are required for the
proper development of the kidney during embryogenesis, but retinoids also play key roles in …