Osteoarthritis: toward a comprehensive understanding of pathological mechanism
Osteoarthritis (OA) is the most common degenerative joint disease and a major cause of
pain and disability in adult individuals. The etiology of OA includes joint injury, obesity …
pain and disability in adult individuals. The etiology of OA includes joint injury, obesity …
Mechanisms of inflammatory responses and development of insulin resistance: how are they interlinked?
Background Insulin resistance (IR) is one of the major hallmark for pathogenesis and
etiology of type 2 diabetes mellitus (T2DM). IR is directly interlinked with various …
etiology of type 2 diabetes mellitus (T2DM). IR is directly interlinked with various …
Macrophages, immunity, and metabolic disease
JC McNelis, JM Olefsky - Immunity, 2014 - cell.com
Chronic, low-grade adipose tissue inflammation is a key etiological mechanism linking the
increasing incidence of type 2 diabetes (T2D) and obesity. It is well recognized that the …
increasing incidence of type 2 diabetes (T2D) and obesity. It is well recognized that the …
The cellular and signaling networks linking the immune system and metabolism in disease
O Osborn, JM Olefsky - Nature medicine, 2012 - nature.com
It is now recognized that obesity is driving the type 2 diabetes epidemic in Western
countries. Obesity-associated chronic tissue inflammation is a key contributing factor to type …
countries. Obesity-associated chronic tissue inflammation is a key contributing factor to type …
Female mice are protected against high-fat diet induced metabolic syndrome and increase the regulatory T cell population in adipose tissue
US Pettersson, TB Waldén, PO Carlsson, L Jansson… - 2012 - journals.plos.org
Sex differences in obesity-induced complications such as type 2 diabetes have been
reported. The aim of the study was to pinpoint the mechanisms resulting in different outcome …
reported. The aim of the study was to pinpoint the mechanisms resulting in different outcome …
Macrophage recruitment in obese adipose tissue
Y Bai, Q Sun - Obesity Reviews, 2015 - Wiley Online Library
Obesity is characterized as a chronic state of low‐grade inflammation with progressive
immune cell infiltration into adipose tissues. Adipose tissue macrophages play critical roles …
immune cell infiltration into adipose tissues. Adipose tissue macrophages play critical roles …
CCR5 plays a critical role in obesity-induced adipose tissue inflammation and insulin resistance by regulating both macrophage recruitment and M1/M2 status
H Kitade, K Sawamoto, M Nagashimada, H Inoue… - Diabetes, 2012 - Am Diabetes Assoc
CC motif chemokine receptor (CCR) 2 and its ligand, monocyte chemoattractant protein
(MCP)-1, are pivotal for adipose tissue macrophage (ATM) recruitment and the development …
(MCP)-1, are pivotal for adipose tissue macrophage (ATM) recruitment and the development …
NOD1 activators link innate immunity to insulin resistance
JD Schertzer, AK Tamrakar, JG Magalhães… - Diabetes, 2011 - Am Diabetes Assoc
OBJECTIVE Insulin resistance associates with chronic inflammation, and participatory
elements of the immune system are emerging. We hypothesized that bacterial elements …
elements of the immune system are emerging. We hypothesized that bacterial elements …
Interleukin-1β mediates macrophage-induced impairment of insulin signaling in human primary adipocytes
Adipose tissue expansion during obesity is associated with increased macrophage
infiltration. Macrophage-derived factors significantly alter adipocyte function, inducing …
infiltration. Macrophage-derived factors significantly alter adipocyte function, inducing …
Innate immunity and adipose tissue biology
A Schäffler, J Schölmerich - Trends in immunology, 2010 - cell.com
The understanding of the role of adipose tissue has changed from a lipid storage organ to
an endocrine and immunologically active organ. Here, we summarize the evidence for an …
an endocrine and immunologically active organ. Here, we summarize the evidence for an …