Beyond antipsychotics: a twenty-first century update for preclinical development of schizophrenia therapeutics

DL Spark, A Fornito, CJ Langmead… - Translational Psychiatry, 2022 - nature.com
Despite 50+ years of drug discovery, current antipsychotics have limited efficacy against
negative and cognitive symptoms of schizophrenia, and are ineffective—with the exception …

More than motor impairment: A spatiotemporal analysis of cognitive impairment and associated neuropathological changes following cortical photothrombotic stroke

S Sanchez-Bezanilla, RJ Hood… - Journal of Cerebral …, 2021 - journals.sagepub.com
There is emerging evidence suggesting that a cortical stroke can cause delayed and remote
hippocampal dysregulation, leading to cognitive impairment. In this study, we aimed to …

Cognitive behavioral markers of neurodevelopmental trajectories in rodents

KHC Choy, JK Luo, CMJ Wannan, L Laskaris… - Translational …, 2021 - nature.com
Between adolescence and adulthood, the brain critically undergoes maturation and
refinement of synaptic and neural circuits that shape cognitive processing. Adolescence also …

The granular retrosplenial cortex is necessary in male rats for object-location associative learning and memory, but not spatial working memory or visual discrimination …

PAS Sheppard, CA Oomen, TJ Bussey, LM Saksida - eneuro, 2024 - eneuro.org
The retrosplenial cortex (RSC) is a hub of diverse afferent and efferent projections thought to
be involved in associative learning. RSC shows early pathology in mild cognitive impairment …

Conditional knock out of transcription factor CTCF in excitatory neurons induces cognitive deficiency

DI Choi, M Kim, S Kim, NK Yu, C Kwak, H Seo, K Lee… - Molecular Brain, 2021 - Springer
CCCTC-binding factor (CTCF) is a transcription factor that is involved in organizing
chromatin structure. A reduction of CTCF expression is known to develop distinct clinical …

Impaired performance of the Q175 mouse model of Huntington's disease in the touch screen paired associates learning task

TO Piiponniemi, T Parkkari, T Heikkinen… - Frontiers in Behavioral …, 2018 - frontiersin.org
Cognitive disturbances often predate characteristic motor dysfunction in individuals with
Huntington's disease (HD) and place an increasing burden on the HD patients and …

Use of an Automated Mouse Touchscreen Platform for Quantification of Cognitive Deficits After Central Nervous System Injury

KM Cotter, GL Bancroft, HA Haas, R Shi… - Neural Repair: Methods …, 2023 - Springer
Analyzing cognitive performance is an important aspect of assessing physiological deficits
after stroke or other central nervous system (CNS) injuries in both humans and in basic …

Neural correlates of feedback processing in visuo-tactile crossmodal paired-associate learning

P Gui, J Li, Y Ku, L Li, X Li, X Zhou, M Bodner… - Frontiers in Human …, 2018 - frontiersin.org
Previous studies have examined the neural correlates for crossmodal paired-associate (PA)
memory and the temporal dynamics of its formation. However, the neural dynamics for …

[图书][B] Behavioural and neurophysiological expression of visual categorization in the mouse medial prefrontal cortex

RCS Pais - 2021 - search.proquest.com
BEHAVIOURAL AND NEUROPHYSIOLOGICAL EXPRESSION OF VISUAL
CATEGORIZATION IN THE MOUSE MEDIAL PREFRONTAL CORTEX RUI CARLOS …

Biological Mediators of Pain, Substance Abuse and Cognitive Impairment in HIV Infection: Sufficiency of the HIV-Tat Protein

TJ Cirino - 2020 - search.proquest.com
Despite the success of combined antiretroviral therapy (cART) in reducing viral load and
sustaining patients infected with the Human Immunodeficiency Virus (HIV), a substantial …