We survive because we adapted to a world of microorganisms. All our epithelial surfaces participate in keeping up an effective barrier against microbes while not initiating ongoing …
RA Sturm, DL Duffy - Genome biology, 2012 - Springer
Genome-wide association studies and comparative genomics have established major loci and specific polymorphisms affecting human skin, hair and eye color. Environmental …
LR Machado, B Ottolini - Frontiers in immunology, 2015 - frontiersin.org
Defensins represent an evolutionary ancient family of antimicrobial peptides that play diverse roles in human health and disease. Defensins are cationic cysteine-containing …
Recent studies in humans and other model organisms have demonstrated that structural variants (SVs) comprise a substantial proportion of variation among individuals of each …
F Semple, H MacPherson, S Webb… - European journal of …, 2011 - Wiley Online Library
Abstract β‐Defensins are cationic host defense peptides that form an amphipathic structure stabilized by three intramolecular disulfide bonds. They are key players in innate and …
INTRODUCTION Characterizing genetic variants underlying local adaptations in human populations is one of the central goals of evolutionary research. Most studies have focused …
P Schmitt, RD Rosa, D Destoumieux-Garzón - Biochimica et biophysica …, 2016 - Elsevier
Antimicrobial peptides and proteins (AMPs) are widespread in the living kingdom. They are key effectors of defense reactions and mediators of competitions between organisms. They …
RC Iskow, O Gokcumen, C Lee - Trends in Genetics, 2012 - cell.com
Over the past decade, the ubiquity of copy number variants (CNVs, the gain or loss of genomic material) in the genomes of healthy humans has become apparent. Although some …
Defensins are short, rapidly evolving, cationic antimicrobial host defence peptides with a repertoire of functions, still incompletely realised, that extends beyond direct microbial …