Alzheimer's disease (AD) is a disorder that causes degeneration of the cells in the brain and
it is the main cause of dementia, which is characterized by a decline in thinking and …

Alzheimer's disease (AD) is a major subtype of neurodegenerative dementia caused by long-
term interactions and accumulation of multiple adverse factors, accompanied by …

The ε4 allele of the apolipoprotein E (APOE) gene is the strongest genetic risk factor for late-
onset Alzheimer's disease (AD) and greatly influences the development of amyloid-β (Aβ) …

Metabolites, the biochemical products of the cellular process, can be used to measure
alterations in biochemical pathways related to the pathogenesis of Alzheimer's disease …

Present review article highlights various cardiovascular risk prediction biomarkers by
incorporating both traditional risk factors to be used as diagnostic markers and recent …

Apolipoprotein E (APOE) is the major cholesterol carrier in the brain, affecting various
normal cellular processes including neuronal growth, repair and remodeling of membranes …

APOE and Trem2 are major genetic risk factors for Alzheimer's disease (AD), but how they
affect microglia response to Aβ remains unclear. Here we report an APOE isoform-specific …

Alzheimer's disease (AD) is the leading cause of dementia worldwide. The extracellular
deposits of Amyloid beta (Aβ) in the brain—called amyloid plaques, and neurofibrillary …

Emerging data suggest that ApoE affects several amyloid β-independent pathways. These
underexplored pathways may provide new insights into Alzheimer's disease pathogenesis …

Cholesterol is a critical component of membrane bilayers where it plays key structural and
functional roles by regulating the activity of diverse signaling platforms and pathways …