DNA methylation plays a critical role in the regulation of chromatin structure and gene
expression and is involved in a variety of biological processes. The levels and patterns of …

Neurodevelopmental disorders (NDDs) are characterized by aberrant and delayed early-life
development of the brain, leading to deficits in language, cognition, motor behaviour and …

The CCCTC-binding factor (CTCF) binds tens of thousands of enhancers and promoters on
mammalian chromosomes by means of its 11 tandem zinc finger (ZF) DNA-binding domain …

Immunodeficiency with centromeric instability and facial anomalies (ICF) syndrome is a
primary immunodeficiency, predominantly characterized by agammaglobulinemia or …

I mmunodeficiency, c entromeric instability, and f acial anomalies (ICF) syndrome is a rare
autosomal recessive disorder characterized by DNA hypomethylation and antibody …

Purpose Autosomal recessive deficiencies of DNMT3B or ZBTB24 account for two-thirds of
cases of immunodeficiency, centromeric instability and facial dysmorphism (ICF syndrome) …

IEIs comprise a group of clinically heterogeneous disorders associated with a number of
nonimmune comorbidities. Although certain neurological conditions such as microcephaly …

Immunodeficiency, centromeric instability and facial anomalies (ICF) syndrome is a rare
autosomal recessive disorder that shows DNA hypomethylation at pericentromeric satellite-2 …

The autosomal recessive immunodeficiency-centromeric instability-facial anomalies
syndrome (ICF) is characterized by immunodeficiency, developmental delay, and facial …

Background Immunodeficiency, centromeric instability, and facial anomalies (ICF) syndrome
is a rare, genetically heterogeneous, autosomal recessive disorder. Patients suffer from …