Therapy-related myeloid neoplasms (t-MN) arise as a late effect of chemotherapy and/or
radiation administered for a primary condition, typically a malignant disease, solid organ …

Somatically acquired genetic abnormalities lead to the salient features that define
myelodysplastic syndromes (MDS): clonal hematopoiesis, aberrant differentiation …

We recently developed fluorescence-activated cell sorting (FACS)-based methods to purify
morphologically and functionally discrete populations of cells, each representing specific …

The casein kinase 1A1 gene (CSNK1A1) is a putative tumor suppressor gene located in the
common deleted region for del (5q) myelodysplastic syndrome (MDS). We generated a …

Understanding how hematopoietic stem cells (HSCs) are generated and the signals that
control this process is a crucial issue for regenerative medicine applications that require in …

The 5q− syndrome is the most distinct of all the myelodysplastic syndromes with a clear
genotype/phenotype relationship. The significant progress made during recent years has …

Myelodysplastic syndrome (MDS) is characterized by bone marrow failure and a strong
propensity for leukemic evolution. Somatic mutations are critical early drivers of the disorder …

Deletions of chromosome 5q are associated with poor outcomes in acute myeloid leukemia
(AML) suggesting the presence of tumor suppressor (s) at the locus. However, definitive …

Within the bone marrow microenvironment, endothelial cells (EC) exert important functions.
Arterial EC support hematopoiesis while H-type capillaries induce bone formation. Here, we …

An interstitial deletion of chromosome 5, del (5q), is the most common structural abnormality
in primary myelodysplastic syndromes (MDS) and therapy-related myeloid neoplasms (t …