The unfolded protein response in immunity and inflammation
J Grootjans, A Kaser, RJ Kaufman… - Nature Reviews …, 2016 - nature.com
The unfolded protein response (UPR) is a highly conserved pathway that allows the cell to
manage endoplasmic reticulum (ER) stress that is imposed by the secretory demands …
manage endoplasmic reticulum (ER) stress that is imposed by the secretory demands …
A molecular web: endoplasmic reticulum stress, inflammation, and oxidative stress
N Chaudhari, P Talwar, A Parimisetty… - Frontiers in cellular …, 2014 - frontiersin.org
Execution of fundamental cellular functions demands regulated protein folding homeostasis.
Endoplasmic reticulum (ER) is an active organelle existing to implement this function by …
Endoplasmic reticulum (ER) is an active organelle existing to implement this function by …
4-PBA inhibits LPS-induced inflammation through regulating ER stress and autophagy in acute lung injury models
M Zeng, W Sang, S Chen, R Chen, H Zhang, F Xue… - Toxicology letters, 2017 - Elsevier
Acute lung injury (ALI) is a common clinical disorder that causes substantial health problems
worldwide. An excessive inflammatory response is the central feature of ALI, but the …
worldwide. An excessive inflammatory response is the central feature of ALI, but the …
The therapeutic effects of 4-phenylbutyric acid in maintaining proteostasis
Recently, there has been an increasing amount of literature published on the effects of 4-
phenylbutyric acid (4-PBA) in various biological systems. 4-PBA is currently used clinically to …
phenylbutyric acid (4-PBA) in various biological systems. 4-PBA is currently used clinically to …
ER stress and the UPR in shaping intestinal tissue homeostasis and immunity
OI Coleman, D Haller - Frontiers in Immunology, 2019 - frontiersin.org
An imbalance in the correct protein folding milieu of the endoplasmic reticulum (ER) can
cause ER stress, which leads to the activation of the unfolded protein response (UPR). The …
cause ER stress, which leads to the activation of the unfolded protein response (UPR). The …
Suppression of Endoplasmic Reticulum Stress by 4-PBA Protects Against Hyperoxia-Induced Acute Lung Injury via Up-Regulating Claudin-4 Expression
HP Pao, WI Liao, SE Tang, SY Wu, KL Huang… - Frontiers in …, 2021 - frontiersin.org
Endoplasmic reticulum (ER) stress that disrupts ER function can occur in response to a wide
variety of cellular stress factors leads to the accumulation of unfolded and misfolded proteins …
variety of cellular stress factors leads to the accumulation of unfolded and misfolded proteins …
Scavenger receptor-A (CD204): a two-edged sword in health and disease
JL Kelley, TR Ozment, C Li… - Critical Reviews™ in …, 2014 - dl.begellhouse.com
ABSTRACT Scavenger receptor A (SR-A), also known as the macrophage scavenger
receptor and cluster of differentiation 204 (CD204), plays roles in lipid metabolism …
receptor and cluster of differentiation 204 (CD204), plays roles in lipid metabolism …
Berberine inhibits free fatty acid and LPS-induced inflammation via modulating ER stress response in macrophages and hepatocytes
Y Wang, X Zhou, D Zhao, X Wang, EC Gurley, R Liu… - PLoS …, 2020 - journals.plos.org
Inflammation plays an essential role in the pathogenesis of non-alcoholic fatty liver disease
(NAFLD). Berberine (BBR), an isoquinoline alkaloid isolated from Chinese medicinal herbs …
(NAFLD). Berberine (BBR), an isoquinoline alkaloid isolated from Chinese medicinal herbs …
Endoplasmic reticulum stress and oxidative stress in inflammatory diseases
Y Tang, X Zhou, T Cao, E Chen, Y Li, W Lei… - DNA and Cell …, 2022 - liebertpub.com
Endoplasmic reticulum (ER) stress and oxidative stress (OS) are often related states in cells
as part of normal physiology but more frequently manifested in the pathophysiology of many …
as part of normal physiology but more frequently manifested in the pathophysiology of many …