Sulfonamide derivatives as potential anti-cancer agents and their SARs elucidation
Y Wan, G Fang, H Chen, X Deng, Z Tang - European Journal of Medicinal …, 2021 - Elsevier
Currently, the arise of drug resistance and undesirable off-target effects of anti-cancer
agents are major challenges for cancer treatment, which energizes medicinal chemists to …
agents are major challenges for cancer treatment, which energizes medicinal chemists to …
Sulfonamide derivatives as multi-target agents for complex diseases
Sulfonamide derivatives are frequently seen structural motifs in medicinal chemistry. Almost
a century after Gerhard Domagk's pioneering work leading to the first sulfonamide antibiotic …
a century after Gerhard Domagk's pioneering work leading to the first sulfonamide antibiotic …
Synthesis, DFT studies, molecular docking and biological activity evaluation of thiazole-sulfonamide derivatives as potent Alzheimer's inhibitors
Alzheimer's disease is a major public brain condition that has resulted in many deaths, as
revealed by the World Health Organization (WHO). Conventional Alzheimer's treatments …
revealed by the World Health Organization (WHO). Conventional Alzheimer's treatments …
Recent advances in the medicinal chemistry of carbonic anhydrase inhibitors
Abstract Carbonic anhydrase (CA, EC 4.2. 1.1) is an enzyme and a very omnipresent zinc
metalloenzyme which catalyzed the reversible hydration and dehydration of carbon dioxide …
metalloenzyme which catalyzed the reversible hydration and dehydration of carbon dioxide …
A decade of tail-approach based design of selective as well as potent tumor associated carbonic anhydrase inhibitors
Human carbonic anhydrase (hCA) isoforms hCA IX and hCA XII are well established
anticancer drug targets and their selective inhibition is highly desired for the proper …
anticancer drug targets and their selective inhibition is highly desired for the proper …
Thiazole-based thiosemicarbazones: Synthesis, cytotoxicity evaluation and molecular docking study
SM Gomha, HA Abdelhady, DZH Hassain… - Drug design …, 2021 - Taylor & Francis
Introduction Hybrid drug design has developed as a prime method for the development of
novel anticancer therapies that can theoretically solve much of the pharmacokinetic …
novel anticancer therapies that can theoretically solve much of the pharmacokinetic …
Thiophene-based derivatives as anticancer agents: An overview on decade's work
S Pathania, PA Chawla - Bioorganic Chemistry, 2020 - Elsevier
Heterocyclic compounds hold a pivotal place in medicinal chemistry due to their wide range
of biological activities and thus, are exhaustively explored in the field of drug design and …
of biological activities and thus, are exhaustively explored in the field of drug design and …
Synthesis, biological evaluation, and molecular docking of novel azolylhydrazonothiazoles as potential anticancer agents
A novel set of thiazolylhydrazonothiazoles bearing an indole moiety were synthesized by
subjection reactions of carbothioamide derivative and hydrazonoyl chlorides (or α …
subjection reactions of carbothioamide derivative and hydrazonoyl chlorides (or α …
Investigation of inhibitory properties of some hydrazone compounds on hCA I, hCA II and AChE enzymes
Recently, inhibition of carbonic anhydrase (hCA) and acetylcholinesterase (AChE) have
appeared as a promising approach for pharmacological intervention in a variety of disorders …
appeared as a promising approach for pharmacological intervention in a variety of disorders …
Synthesis and bioactivities of pyrazoline benzensulfonamides as carbonic anhydrase and acetylcholinesterase inhibitors with low cytotoxicity
(3-Substitutedphenyl-5-polymethoxyphenyl-4, 5-dihydro-1H-pyrazol-1-yl)
benzenesulfonamides (9–16) were synthesized and their chemical structures were …
benzenesulfonamides (9–16) were synthesized and their chemical structures were …