Molecular imaging of opioid and dopamine systems: insights into the pharmacogenetics of opioid use disorders
JA Burns, DS Kroll, DE Feldman, C Kure Liu… - Frontiers in …, 2019 - frontiersin.org
Opioid use in the United States has steadily risen since the 1990s, along with staggering
increases in addiction and overdose fatalities. With this surge in prescription and illicit opioid …
increases in addiction and overdose fatalities. With this surge in prescription and illicit opioid …
Endocannabinoid signaling in psychiatric disorders: a review of positron emission tomography studies
Endocannabinoid signaling is implicated in an array of psychopathologies ranging from
anxiety to psychosis and addiction. In recent years, radiotracers targeting the …
anxiety to psychosis and addiction. In recent years, radiotracers targeting the …
The effects of psychosocial stress on dopaminergic function and the acute stress response
Chronic psychosocial adversity induces vulnerability to mental illnesses. Animal studies
demonstrate that this may be mediated by dopaminergic dysfunction. We therefore …
demonstrate that this may be mediated by dopaminergic dysfunction. We therefore …
The relationship between cortical glutamate and striatal dopamine in first-episode psychosis: a cross-sectional multimodal PET and magnetic resonance spectroscopy …
Background The pathophysiology of psychosis is incompletely understood. Disruption in
cortical glutamatergic signalling causing aberrant striatal dopamine synthesis capacity is a …
cortical glutamatergic signalling causing aberrant striatal dopamine synthesis capacity is a …
Epigenetic aging is accelerated in alcohol use disorder and regulated by genetic variation in APOL2
A Luo, J Jung, M Longley, DB Rosoff… - …, 2020 - nature.com
To investigate the potential role of alcohol use disorder (AUD) in aging processes, we
employed Levine's epigenetic clock (DNAm PhenoAge) to estimate DNA methylation age in …
employed Levine's epigenetic clock (DNAm PhenoAge) to estimate DNA methylation age in …
Low status, humiliation, dopamine and risk of schizophrenia
The social defeat hypothesis of schizophrenia, which proposes that the chronic experience
of outsider status or subordinate position leads to increased striatal dopamine activity and …
of outsider status or subordinate position leads to increased striatal dopamine activity and …
A polygenic score indexing a DRD2-related co-expression network is associated with striatal dopamine function
The D2 dopamine receptor (D2R) is the primary site of the therapeutic action of
antipsychotics and is involved in essential brain functions relevant to schizophrenia, such as …
antipsychotics and is involved in essential brain functions relevant to schizophrenia, such as …
Effects of sedative drug use on the dopamine system: a systematic review and meta-analysis of in vivo neuroimaging studies
Use of alcohol, cannabis and opioids is highly prevalent and is associated with global
disease burden and high economic costs. The exact pathophysiology of abuse or addiction …
disease burden and high economic costs. The exact pathophysiology of abuse or addiction …
Addressing structural racism in psychiatry with steps to improve psychophysiologic research
Importance The American Medical Association has acknowledged the public health threat
posed by racism in medicine. While clinicians in psychiatry have echoed the sentiment, the …
posed by racism in medicine. While clinicians in psychiatry have echoed the sentiment, the …
Chronic social stressors and striatal dopamine functioning in humans: A systematic review of SPECT and PET studies
R Schalbroeck, CFM van Hooijdonk, DPA Bos… - Molecular …, 2024 - nature.com
The dopamine hypothesis of schizophrenia posits that elevated striatal dopamine
functioning underlies the development of psychotic symptoms. Chronic exposure to social …
functioning underlies the development of psychotic symptoms. Chronic exposure to social …