The ability of living systems to adapt to changing conditions originates from their capacity to
change their molecular constitution. This is achieved by multiple mechanisms that modulate …

Transient interactions, which involve protein interactions that are formed and broken easily,
are important in many aspects of cellular function. Here we describe structural and functional …

Transient complexes are crucial for diverse biological processes such as biochemical
pathways and signaling cascades in the cell. Here, we give an overview of the transient …

Cells face a constant challenge as they produce new proteins. The newly synthesized
polypeptides must be folded properly to avoid aggregation. If proteins do misfold, they must …

Proteins may vary from being rigid to having flexible regions to being completely disordered,
either as an intrinsically disordered protein (IDP) or having specific intrinsically disordered …

High-quality datasets are needed to understand how global and local properties of protein-
protein interaction, or'interactome', networks relate to biological mechanisms, and to guide …

Analysis of proteins commonly requires the partition of their structure into regions such as
the surface, interior, or interface. Despite the frequent use of such categorization, no …

The challenging task of studying and modeling complex dynamics of biological systems in
order to describe various human diseases has gathered great interest in recent years. Major …

The finding that a large fraction of proteins (over 30%) in eukaryotic cells lack a unique three-
dimensional structure but are functional has forced the scientific community to review its …

Cellular processes are typically carried out by protein complexes and functional modules.
Identifying them plays an important role for our attempt to reveal principles of cellular …