Alzheimer's disease (AD) is a neurodegenerative disease associated with human aging.
Ten percent of individuals over 65 years have AD and its prevalence continues to rise with …

Chronic, excessive neuroinflammation is a key feature of neurodegenerative diseases such
as Alzheimer's disease (AD) and Parkinson's disease (PD). However, neuroinflammatory …

Objective Evaluating the efficacy of 3, 6'‐dithioPomalidomide in 5xFAD Alzheimer's disease
(AD) mice to test the hypothesis that neuroinflammation is directly involved in the …

Cerebral dopamine neurotrophic factor (CDNF) is an unconventional neurotropic factor that
modulates unfolded protein response (UPR) pathway signaling and alleviates endoplasmic …

Microglial cells are the neuroimmune competent cells of the central nervous system. In the
adult, microglia are responsible for screening the neuronal parenchyma searching for …

The immunomodulatory imide drug (IMiD) class, which includes the founding drug member
thalidomide and later generation drugs, lenalidomide and pomalidomide, has dramatically …

Traumatic brain injury (TBI) is linked to several pathologies. The blood-brain barrier (BBB)
breakdown is considered to be one of the initial changes. Further, the microenvironmental …

Osteosarcoma is the most common skeletal malignancy and is the second leading cause of
cancer death in adolescents. Its highly aggressive nature and high propensity to metastasize …

Neuroinflammation represents a common trait in the pathology and progression of the major
psychiatric and neurodegenerative disorders. Neuropsychiatric disorders have emerged as …

According to the World Health Organization, Traumatic brain injury (TBI) is the major cause
of death and disability and will surpass the other diseases by the year 2020. Patients who …