Using the bipartite human phenotype network to reveal pleiotropy and epistasis beyond the gene
With the rapid increase in the quality and quantity of data generated by modern high-
throughput sequencing techniques, there has been a need for innovative methods able to …
throughput sequencing techniques, there has been a need for innovative methods able to …
The multiscale backbone of the human phenotype network based on biological pathways
C Darabos, MJ White, BE Graham, DN Leung… - BioData Mining, 2014 - Springer
Background Networks are commonly used to represent and analyze large and complex
systems of interacting elements. In systems biology, human disease networks show …
systems of interacting elements. In systems biology, human disease networks show …
A bipartite network approach to inferring interactions between environmental exposures and human diseases
C Darabos, ED Grussing, ME Cricco… - Pacific symposium on …, 2014 - World Scientific
Environmental exposure is a key factor of understanding health and diseases. Beyond
genetic propensities, many disorders are, in part, caused by human interaction with harmful …
genetic propensities, many disorders are, in part, caused by human interaction with harmful …
Studying the Genetics of Complex Disease With Ancestry‐Specific Human Phenotype Networks: The Case of Type 2 Diabetes in East Asian Populations
Genome‐wide association studies (GWAS) have led to the discovery of over 200 single
nucleotide polymorphisms (SNPs) associated with type 2 diabetes mellitus (T2DM) …
nucleotide polymorphisms (SNPs) associated with type 2 diabetes mellitus (T2DM) …
Genome-wide genetic interaction analysis of glaucoma using expert knowledge derived from human phenotype networks
The large volume of GWAS data poses great computational challenges for analyzing genetic
interactions associated with common human diseases. We propose a computational …
interactions associated with common human diseases. We propose a computational …
An integrated network approach to identifying biological pathways and environmental exposure interactions in complex diseases
Complex diseases are the result of intricate interactions between genetic, epigenetic and
environmental factors. In previous studies, we used epidemiological and genetic data linking …
environmental factors. In previous studies, we used epidemiological and genetic data linking …
Genome-wide epistasis and pleiotropy characterized by the bipartite human phenotype network
Networks are central to turning the colossal amount of information generated by high-
throughput genetic technology into manageable sources of knowledge. They are an intuitive …
throughput genetic technology into manageable sources of knowledge. They are an intuitive …
Evolutionarily derived networks to inform disease pathways
BE Graham, C Darabos, M Huang… - Genetic …, 2017 - Wiley Online Library
Methods to identify genes or pathways associated with complex diseases are often
inadequate to elucidate most risk because they make implicit and oversimplified …
inadequate to elucidate most risk because they make implicit and oversimplified …
Network-based methods for analyzing the genetics of human complexdiseases
GS de Araújo - 2017 - repositorio.ufmg.br
Interpreting the high volume of genomic data is a challenge for epidemiologists,
anthropologists and geneticists that aim to understand the genetic basis of populations and …
anthropologists and geneticists that aim to understand the genetic basis of populations and …
[引用][C] The multiscale backbone of the human phenotype network based on biological pathways
JH Moore, SM Williams, DN Leung, BE Graham… - 2014