The topic of this chapter, transient receptor potential ankyrin 1 (TRPA1), is a calcium-
permeable nonselective cation channel that is a member of the TRP family expressed on …

Following colonic inflammation, the uninjured bladder afferent neurons are also activated.
The mechanisms and pathways underlying this sensory neuron cross-activation (from …

Functionally distinct subtypes/clusters of dorsal root ganglion (DRG) neurons may play
different roles in nerve regeneration and pain. However, details about their transcriptomic …

Cannabis sativa plants contain a multitude of bioactive substances, which show broad
variability between different plant strains. Of the more than a hundred naturally occurring …

Primary afferent nociceptors can “listen” to immune cells by sensing cytokines that are
released at the site of acute inflammation or maintained inflammatory processes in case of …

Neuropathic pain is a chronic condition that tends to worsen over time, leading to a
significant decline in patients' quality of life. The elderly population is disproportionately …

Debilitating abdominal pain is a common symptom affecting most patients with chronic
pancreatitis (CP). There are multiple underlying mechanisms that contribute to CP-related …

TRPA1 channels have been implicated in mechanical and cold hypersensitivity in chronic
pain. But how TRPA1 mediates this process is unclear. Here we show that IQ motif …

Abstract Voltage-gated K+ (KV) channels govern K+ ion flux across cell membranes in
response to changes in membrane potential. They are formed by the assembly of four …