The intestinal lamina propria (LP) contains a diverse array of mononuclear phagocyte (MNP)
subsets, including conventional dendritic cells (cDC), monocytes and tissue-resident …

The T helper 17 (Th17) cells represent a subset of CD4+ T-cells with unique effector
functions, developmental plasticity, and stem-cell features. Th17 cells bridge innate and …

Regulatory T cells (Tregs) are required to establish immune tolerance to commensal
microbes. Tregs accumulate abruptly in the skin during a defined window of postnatal tissue …

T cell immunity is essential for the control of tuberculosis (TB), an important disease of the
lung, and is generally studied in humans using peripheral blood cells. Mounting evidence …

Objectives: The objective of this article is to investigate the contribution of colon and blood
CD4+ T-cell subsets expressing the chemokine receptor CCR6 to HIV persistence during …

Objective Hepatitis E virus (HEV), one of the most common agent of acute hepatitis
worldwide, is mainly transmitted enterically, via contaminated water for HEV genotypes 1 …

Gut-associated lymphoid tissues are enriched in CCR6+ Th17-polarized CD4+ T cells that
contribute to HIV-1 persistence during antiretroviral therapy (ART). This raises the need for …

Background The persistence of intact replication-competent HIV-1 proviruses is responsible
for the virological rebound off treatment. The gut could be a major reservoir of HIV-1 due to …

Background Identifying where human immunodeficiency virus (HIV) persists in people living
with HIV and receiving antiretroviral therapy is critical to develop cure strategies. We …

Background HIV infection promotes the expansion of immunosuppressive regulatory T-cells
(Tregs), contributing to immune dysfunction, tissue fibrosis and disease progression. Early …