Among all tumor suppressor microRNAs, reduced let-7 expression occurs most frequently in
cancer and typically correlates with poor prognosis. Activation of either LIN28A or LIN28B …

Atypical teratoid/rhabdoid tumor (AT/RT) is the most common malignant CNS tumor of
children below 6 months of age. The majority of AT/RTs demonstrate genomic alterations in …

Purpose: The cyclin-dependent kinase (CDK) 4/6 inhibitor, ribociclib (LEE011), displayed
preclinical activity in neuroblastoma and malignant rhabdoid tumor (MRT) models. In this …

Recent years have witnessed a shift to more objective and biologically-driven methods for
central nervous system (CNS) tumor classification. The 2016 world health organization …

Background The understanding of molecular alterations of tumors has severely changed the
concept of classification in all fields of pathology. The availability of high-throughput …

Atypical teratoid/rhabdoid tumor (AT/RT) is a highly malignant embryonal central nervous
system tumor commonly affecting children< 3 years of age. It roughly constitutes 1%–2% of …

Atypical teratoid rhabdoid tumors (AT/RT) are malignant central nervous system (CNS)
tumors that occur mostly in young children and have historically carried a very poor …

Extracranial malignant rhabdoid tumors (extracranial MRT) are rare, highly aggressive
malignancies affecting mainly infants and children younger than 3 years. Common anatomic …

Children with Group 3 medulloblastoma (G3 MB) have a very poor prognosis, and many do
not survive beyond 5 years after diagnosis. A factor that may contribute to this is the lack of …

NOTCH regulates stem cells during normal development and stemlike cells in cancer, but
the roles of NOTCH in the lethal pediatric brain tumor diffuse intrinsic pontine glioma (DIPG) …