Voltage-gated ion channels are crucial for both neuronal and cardiac excitability. Decades
of research have begun to unravel the intriguing machinery behind voltage sensitivity …

Covering: up to 2006Advances in NMR and mass spectrometry as well as in peptide
biochemistry coupled to modern methods in electrophysiology have permitted the isolation …

Loss-of-function mutations in the human voltage-gated sodium channel NaV1. 7 result in a
congenital indifference to pain. Selective inhibitors of NaV1. 7 are therefore likely to be …

Delayed-rectifier K+ currents (IDR) in pancreatic β-cells are thought to contribute to action
potential repolarization and thereby modulate insulin secretion. The voltage-gated K+ …

Centipedes are excellent predatory arthropods that inject venom to kill or immobilize their
prey. Although centipedes have long been known to be venomous, their venoms remain …

Background Kuntiz-type toxins (KTTs) have been found in the venom of animals such as
snake, cone snail and sea anemone. The main ancestral function of Kunitz-type proteins …

Spider venoms are a rich source of novel pharmacologically and agrochemically interesting
compounds that have received increased attention from pharmacologists and biochemists in …

Spider venom-derived cysteine knot peptides are a mega-diverse class of molecules that
exhibit unique pharmacological properties to modulate key membrane protein targets …

Blockade of voltage‐gated sodium channels (VGSCs) has been used successfully in the
clinic to enable control of pathological firing patterns that occur in conditions as diverse as …

Animal venoms are a rich source of bioactive peptides that efficiently modulate key receptors
and ion channels involved in cellular excitability to rapidly neutralize their prey or predators …