Recent evidence has elucidated how multipotent blood progenitors transform their identities
in the thymus and undergo commitment to become T cells. Together with environmental …

TCF1 and its homologue LEF1 are historically known as effector transcription factors
downstream of the WNT signalling pathway and are essential for early T cell development …

The Wnt signaling pathway is critically involved in both the development and homeostasis of
tissues via regulation of their endogenous stem cells. Aberrant Wnt signaling has been …

WNT–β-catenin signalling is involved in a multitude of developmental processes and the
maintenance of adult tissue homeostasis by regulating cell proliferation, differentiation …

The bone marrow niche has mystified scientists for many years, leading to widespread
investigation to shed light into its molecular and cellular composition. Considerable efforts …

Recent advances have redefined a role for T cell factor 1 (TCF1) that goes beyond T cell
development and T memory formation and encompasses new functions in the regulation of …

Metastatic growth in distant organs is the major cause of cancer mortality. The development
of metastasis is a multistage process with several rate-limiting steps. Although dissemination …

Transplantation of hematopoietic stem cells (HSCs) from human umbilical cord blood
(hUCB) holds great promise for treating a broad spectrum of hematological disorders …

Stem cells are defined by the ability to self-renew and to generate differentiated progeny,
qualities that are maintained by evolutionarily conserved pathways that can lead to cancer …

The mammalian blood system, containing more than 10 distinct mature cell types, stands on
one specific cell type, hematopoietic stem cell (HSC). Within the system, only HSCs possess …