Several regulatory guidances on the use of physiologically based pharmacokinetic (PBPK)
analyses and physiologically based biopharmaceutics model (s)(PBBM (s)) have been …

High solubility in water and physiological fluids is an indispensable requirement for the
pharmacological efficacy of an active pharmaceutical ingredient. Indeed, it is well …

Anatomical/physiological gastrointestinal changes after bariatric surgery may influence the
fate of orally administered drugs. Since non-selective NSAIDs are not well-tolerated post …

Gastrointestinal anatomical/physiological changes after bariatric surgery influence variables
affecting the fate of drugs after ingestion, and medication management of these patients …

Abstract pH-mediated drug-drug interactions (DDI) is a prevalent DDI in drug development,
especially for weak base compounds with highly pH-dependent solubility. FDA has released …

A TIM-1 model is an in vitro gastrointestinal (GI) simulator considering crucial physiological
parameters that will affect the in vivo drug release process. The outcome of these …

It is well known that reduced gastric acidity, for example with concomitant administration of
acid reducing agents, can result in variable pharmacokinetics and decreased absorption of …

Curcumin (Cur) is a beneficial compound, but its efficacy is limited due to its poor aqueous
solubility. The objective of this study was to develop and optimize Cur-nanosuspensions …

Deconvolution and convolution are powerful tools that allow decomposition and
reconstruction, respectively, of plasma versus time profiles from input and impulse functions …

Introduction Amorphous solid dispersion (ASD) technique has recently been used as an
effective formulation strategy to significantly improve the bioavailability of insoluble drugs …