Emerging applications of nanotechnology in healthcare systems: Grand challenges and perspectives

S Anjum, S Ishaque, H Fatima, W Farooq, C Hano… - Pharmaceuticals, 2021 - mdpi.com
Healthcare, as a basic human right, has often become the focus of the development of
innovative technologies. Technological progress has significantly contributed to the …

[HTML][HTML] Nanoparticle-mediated brain drug delivery: Overcoming blood–brain barrier to treat neurodegenerative diseases

C Saraiva, C Praça, R Ferreira, T Santos… - Journal of controlled …, 2016 - Elsevier
The blood–brain barrier (BBB) is a vital boundary between neural tissue and circulating
blood. The BBB's unique and protective features control brain homeostasis as well as ion …

Peptide and protein nanoparticle conjugates: versatile platforms for biomedical applications

CD Spicer, C Jumeaux, B Gupta… - Chemical Society …, 2018 - pubs.rsc.org
Peptide–and protein–nanoparticle conjugates have emerged as powerful tools for
biomedical applications, enabling the treatment, diagnosis, and prevention of disease. In …

Gold nanostructures: synthesis, properties, and neurological applications

I Zare, MT Yaraki, G Speranza, AH Najafabadi… - Chemical society …, 2022 - pubs.rsc.org
Recent advances in technology are expected to increase our current understanding of
neuroscience. Nanotechnology and nanomaterials can alter and control neural functionality …

Surface modification of gold nanoparticles with neuron-targeted exosome for enhanced blood–brain barrier penetration

M Khongkow, T Yata, S Boonrungsiman… - Scientific reports, 2019 - nature.com
Gold nanoparticles (AuNPs) have been extensively used as nanomaterials for theranostic
applications due to their multifunctional characteristics in therapeutics, imaging, and surface …

Key for crossing the BBB with nanoparticles: The rational design

SM Lombardo, M Schneider, AE Türeli… - Beilstein journal of …, 2020 - beilstein-journals.org
Central nervous system diseases are a heavy burden on society and health care systems.
Hence, the delivery of drugs to the brain has gained more and more interest. The brain is …

Peptide–nanoparticle conjugates: a next generation of diagnostic and therapeutic platforms?

W Jeong, J Bu, LJ Kubiatowicz, SS Chen, YS Kim… - Nano …, 2018 - Springer
Peptide–nanoparticle conjugates (PNCs) have recently emerged as a versatile tool for
biomedical applications. Synergism between the two promising classes of materials allows …

Whole-blood metabolomics of dementia patients reveal classes of disease-linked metabolites

T Teruya, YJ Chen, Y Fukuji, H Kondoh… - Proceedings of the …, 2021 - pnas.org
Dementia is caused by factors that damage neurons. We quantified small molecular markers
in whole blood of dementia patients, using nontargeted liquid chromatography–mass …

Surface engineering of iron oxide nanoparticles for targeted cancer therapy

FM Kievit, M Zhang - Accounts of chemical research, 2011 - ACS Publications
Nanotechnology provides a flexible platform for the development of effective therapeutic
nanomaterials that can interact specifically with a target in a biological system and provoke a …

Delivery of gold nanoparticles to the brain by conjugation with a peptide that recognizes the transferrin receptor

R Prades, S Guerrero, E Araya, C Molina, E Salas… - Biomaterials, 2012 - Elsevier
The treatment of Alzheimer's disease and many other brain-related disorders is limited
because of the presence of the blood–brain barrier, which highly regulate the crossing of …