Alzheimer's disease (AD) is a neurodegenerative disorder, most cases of which lack a clear
causative event. This has made the disease difficult to characterize and, thus, diagnose …

beta-Amyloid precursor protein (beta-APP), the source of the fibrillogenic amyloid beta-
peptide (A beta) that accumulates in the brain of victims of Alzheimer's disease, is a …

Zinc is an important trace element in biology. An important pool of zinc in the brain is the one
present in synaptic vesicles in a subgroup of glutamatergic neurons. In this form it can be …

Amyloid β peptide (Aβ)-containing plaques are a hallmark of Alzheimer disease. Here, we
show that the neurotoxic Aβ, a major plaque component, is a potent activator of the …

Aspirin (acetylsalicylic acid) is a commonly prescribed drug with a wide pharmacological
spectrum. At concentrations compatible with amounts in plasma during chronic anti …

Although, better known for its role in inflammation, the transcription factor nuclear factor
kappa B (NF-κB) has more recently been implicated in synaptic plasticity, learning, and …

Nuclear factor kappa B (NF-κB) is an inducible transcription factor present in neurons and
glia. Recent genetic models identified a role for NF-κB in neuroprotection against various …

Members of the nuclear factor κB (NF-κB) family of transcription factors are activated within
the CNS in pathological settings of apoptosis and neurological disease. Recent work using …

Objective The present work evaluates the relationship between postoperative immune and
neurovascular changes and the pathogenesis of surgery‐induced delirium superimposed …

Neuroinflammation is significant in the pathogenesis and development of Alzheimer's
disease (AD). Previously, we showed lipopolysaccharide (LPS)-induced neuroinflammation …