Felty's syndrome was first described in 1924 by the US-American physician Augustus Roi
Felty as a triad of rheumatoid arthritis, splenomegaly and leucopenia. Even nearly 100 years …

In this article, we will share lessons that patients with gain-of-function defects in Toll-like
receptor 8 (TLR8-GOF) can teach us about the interface between bone marrow failure (BMF) …

Low-risk myelodysplastic syndromes (LR-MDS) are a very heterogeneous disease, with
extremely variable clinical features and outcome. Therapeutic strategies are still limited and …

Background Liver and kidney damage associated with lead acetate exposure has been
reported to involve membrane disruption and renal tubuloglomerular dysfunctions which …

Next-generation sequencing (NGS) has demonstrated the existence of recurrent activating
mutations in STAT3 and STAT5B in~ 40% to 50% of patients with T-cell large granular …

BACKGROUND Myelodysplastic syndrome (MDS) is caused by malignant proliferation and
ineffective hematopoiesis. Oncogenic somatic mutations and increased apoptosis …

Simple Summary The clonal expansions of large granular lymphocytes are frequently
detected in a wide spectrum of hematological and immune diseases. This clinical overlap …

T-cell large granular lymphocyte leukemia (T-LGL) is often accompanied by pure red cell
aplasia (PRCA). A high depth of next generation sequencing (NGS) was used for detection …

Background Concern about post-CAR T-cell lymphomas has recently emerged. Analysis of
pharmacovigilance data contributes to continuous safety monitoring, especially for newly …

Cytauxzoonosis is caused by Cytauxzoon felis (C. felis), a tick-borne parasite that causes
severe disease in domestic cats in the United States. Currently, there is no vaccine to …