Biological membranes exhibit various function-related shapes, and the mechanism by which
these shapes are created is largely unclear. Here, we classify possible curvature-generating …

1956 some simple imperfections have been visualised in crystal structures of model
peptides (Bella et al., 2006). Integrin adhesion sequences [eg Arg-Gly-Asp (RGD) and Gly …

Deregulation of Akt/protein kinase B (PKB) is implicated in the pathogenesis of cancer and
diabetes. Akt/PKB activation requires the phosphorylation of Thr308 in the activation loop by …

Signaling through the Ror2 receptor tyrosine kinase promotes invadopodia formation for
tumor invasion. Here, we identify intraflagellar transport 20 (IFT20) as a new target of this …

Collagen fibrils in the extracellular matrix allow connective tissues such as tendon, skin and
bone to withstand tensile forces. The fibrils are indeterminate in length, insoluble and form …

Protein traffic moving from the endoplasmic reticulum (ER) to the Golgi complex in
mammalian cells passes through the tubulovesicular membrane clusters of the ER-Golgi …

Metastasis is a multistep biological process regulated by multiple signaling pathways. The
integrity of the Golgi apparatus plays an important role in these signaling pathways. Inspired …

The composition and identity of cell organelles are dictated by the flux of lipids and proteins
that they receive and lose through cytosolic exchange and membrane trafficking. The trans …

The molecular machinery responsible for the generation of transport carriers moving from
the Golgi complex to the plasma membrane relies on a tight interplay between proteins and …

The Golgi apparatus is composed of biochemically distinct early (cis, medial) and late (trans,
TGN) cisternae. There is debate about the nature of these cisternae,,. The stable …