Hematologic malignancies (HMs) pose a serious threat to patients' health and life, and the
five-year overall survival of HMs remains low. The lack of understanding of the pathogenesis …

How position-dependent cell fate acquisition occurs during embryogenesis is a central
question in developmental biology. To study this process, we developed a defined, high …

Human pluripotent stem cells (hPSCs) have been suggested as a potential source for the de
novo production of blood cells for transfusion, immunotherapies, and transplantation …

Understanding the pathways guiding the development of definitive hematopoiesis with
lymphoid potential is essential for advancing human pluripotent stem cell (hPSC) …

Background Human induced pluripotent stem cells (hiPSCs) offer a renewable source of
cells for the generation of hematopoietic cells for cell-based therapy, disease modeling, and …

Functional assessment of stem cell‐mediated endogenous repair relies on animal studies.
Here an in vitro assay is described that recapitulates important early steps of the in vivo …

During embryonic development, hematopoiesis occurs through primitive and definitive
waves, giving rise to distinct blood lineages. Hematopoietic stem cells (HSCs) emerge from …

Pyruvate Kinase Deficiency (PKD) is a rare erythroid metabolic disease caused by mutations
in the PKLR gene, which encodes the erythroid specific Pyruvate Kinase enzyme …

Precursors of the adult hematopoietic system arise from the aorta-gonad-mesonephros
(AGM) region shortly after the embryonic circulation is established. Here, we develop a …

Precise manipulation of human cell fate is a long-standing goal in biological engineering; it
underpins efforts to advance new cellular therapeutics, and to develop disease models for …