Epileptogenesis in infants with tuberous sclerosis complex (TSC) is a gradual and dynamic
process, leading to early onset and difficult-to-treat seizures. Several cellular, molecular and …

Ethnopharmacological relevance Epilepsy is one of the most prevalent neurological human
diseases, affecting 1% of the population in all age groups. Despite the availability of over 25 …

Tuberous sclerosis complex (TSC) is a rare multisystem disorder caused by heterozygous
loss-of-function pathogenic variants in the tumour suppressor genes TSC1 and TSC2 …

Approximately 22% of Alzheimer's disease (AD) patients suffer from seizures, and the co-
occurrence of seizures and epileptiform activity exacerbates AD pathology and related …

The mechanistic target of rapamycin complex 1 (mTORC1) signaling pathway is a
ubiquitous cellular pathway. mTORopathies, a group of disorders characterized by …

The hippocampus is one of the brain areas affected by autism spectrum disorder (ASD).
Individuals with ASD typically have impairments in hippocampus-dependent learning …

Epilepsy remains a major health concern as anti-seizure medications frequently fail, and
there is currently no treatment to stop or prevent epileptogenesis, the process underlying the …

Sleep-related hypermotor epilepsy (SHE) is a focal epilepsy syndrome characterized by a
variable age of onset and heterogeneous etiology. Current literature suggests a prevalence …

Background Tuberous sclerosis complex (TSC) is an autosomal dominant genetic disorder
with a birth incidence of 1: 6000 in the United States that is characterized by the growth of …

Background and objectives Neuroinflammation contributes to the severity of various
neurological disorders, including epilepsy. Tuberous sclerosis complex (TSC) is a condition …