Thoracic aortic disease affects people of all ages and the majority of those aged< 60 years
have an underlying genetic cause. There is presently no effective medical therapy for …

ABSTRACT Introduction: The Notch pathway is involved in determining cell fate during
development and postnatally in continuously renewing tissues, such as the endothelium, the …

Backgound: The inability to detect premature atherosclerosis significantly hinders
implementation of personalized therapy to prevent coronary heart disease. A …

Bicuspid aortic valve (BAV) is a common congenital heart defect (population incidence, 1–
2%),–that frequently presents with ascending aortic aneurysm (AscAA). BAV/AscAA shows …

Background A bicuspid aortic valve (BAV) is the most common congenital cardiac
malformation. The development of the aortic valve is closely related to the development of …

Degenerative ascending aortic aneurysm (AscAA) is a silent and potentially fatal disease
characterized by excessive vascular inflammation and fibrosis. We aimed to characterize the …

(1) Background: The pathophysiologic basis of an acute type A aortic dissection (TAAD) is
largely unknown. In an effort to evaluate vessel wall defects, we systematically studied aortic …

Rationale: The pathogenesis of bicuspid aortic valve (BAV)–associated aortopathy is poorly
understood, and no prognostic biomarker is currently available. Objective: We aimed to …

The aortopathy associated with bicuspid aortic valve (BAV) is an epidemiologically relevant
source of chronic and acute aortic disease (aneurysm and dissection). However, its …

Background Ascending aortic aneurysms constitute an important hazard for individuals with
a bicuspid aortic valve (BAV). However, the processes that degrade the aortic wall in BAV …