Meta-analyses of genome-wide association studies (meta-GWASs) and candidate gene
studies have identified genetic variants associated with cardiovascular diseases, metabolic …

Cholesterol homeostasis is essential in normal physiology of all cells. One of several
proteins involved in cholesterol homeostasis is the ATP-binding cassette transporter A1 …

With the identification of ChREBP in 2001, our interest in understanding the molecular
control of carbohydrate sensing has surged. While ChREBP was initially studied as a master …

Lipoprotein lipase (LPL) is a rate-limiting enzyme for hydrolysing circulating triglycerides
(TG) into free fatty acids that are taken up by peripheral tissues. Postprandial LPL activity …

Hypercholesterolemia is a strong determinant of mortality and morbidity associated with
cardiovascular diseases and a major contributor to the global disease burden. Mutations in …

Genome analysis of diverse human populations has contributed to the identification of novel
genomic loci for diseases of major clinical and public health impact. Here, we report a …

Diseases such as Huntington's disease and certain spinocerebellar ataxias are caused by
the expansion of genomic cytosine-adenine-guanine (CAG) trinucleotide repeats beyond a …

Lipasin/Angptl8 is a feeding-induced hepatokine that regulates triglyceride (TAG)
metabolism; its therapeutical potential, mechanism of action and relation to the lipoprotein …

Some high-carbohydrate diets may lead to obesity and multiple metabolic disorders,
including hypertriglyceridemia (HTG). This lipid abnormality is considered an important risk …

Dyslipidemia and obesity are especially prevalent in populations with Amerindian
backgrounds, such as Mexican–Americans, which predispose these populations to …