Over the past decade, technical and methodological improvements in cryogenic electron
microscopy (cryo-EM) single-particle analysis have enabled routine high-resolution …

The power of computer simulations, including machine‐learning, has become an
inseparable part of scientific analysis of biological data. This has significantly impacted the …

The S: A222V point mutation, within the G clade, was characteristic of the 20E (EU1) SARS-
CoV-2 variant identified in Spain in early summer 2020. This mutation has since reappeared …

Cyanobacteria, glaucophytes, and rhodophytes utilize giant, light-harvesting phycobilisomes
(PBSs) for capturing solar energy and conveying it to photosynthetic reaction centers. PBSs …

Using a new consensus-based image-processing approach together with principal
component analysis, the flexibility and conformational dynamics of the SARS-CoV-2 spike in …

In response to improper kinetochore-microtubule attachments in mitosis, the spindle
assembly checkpoint (SAC) assembles the mitotic checkpoint complex (MCC) to inhibit the …

An open-source Python library EMDA for cryo-EM map and model manipulation is presented
with a specific focus on validation. The use of several functionalities in the library is …

Resolving the structural variability of proteins is often key to understanding the structure–
function relationship of those macromolecular machines. Single particle analysis using …

Ion channels are expressed in almost all living cells, controlling the in-and-out
communications, making them ideal drug targets, especially for central nervous system …

Flexible fitting based on molecular dynamics simulation is a technique for structure modeling
from cryo-EM data. It has been utilized for nearly two decades, and while cryo-EM resolution …