Abstract Protein Phosphatase 2A (PP2A) encompasses a large family of Ser/Thr
phosphatases, consisting of a catalytic C subunit and a structural A subunit that are, in most …

Neurodevelopmental disorders (NDDs), including intellectual disability (ID), autism and
schizophrenia, have high socioeconomic impact, yet poorly understood etiologies. A recent …

Although mutations in the gene encoding the RNA splicing factor SF3B1 are frequent in
multiple cancers, their functional effects and therapeutic dependencies are poorly …

In cancer, kinases are often activated and phosphatases suppressed, leading to aberrant
activation of signaling pathways driving cellular proliferation, survival, and therapeutic …

By removing Ser/Thr-specific phosphorylations in a multitude of protein substrates in diverse
tissues, Protein Phosphatase type 2A (PP2A) enzymes play essential regulatory roles in …

Protein phosphorylation is a ubiquitous cellular process that allows for the nuanced and
reversible regulation of protein activity. Protein phosphatase 2A (PP2A) is a heterotrimeric …

Type II endometrial carcinomas (ECs) are responsible for most endometrial cancer-related
deaths due to their aggressive nature, late stage detection and high tolerance for standard …

Lung cancer (LC) has the highest relative risk of development as a comorbidity of chronic
obstructive pulmonary disease (COPD). The molecular mechanisms that mediate chronic …

KRAS-mutant lung adenocarcinomas represent the largest molecular subgroup of non-small
cell lung cancers (NSCLC) and are notorious for their dismal survival perspectives. To gain …

The serine/threonine protein phosphatase 2A (PP2A) is a master regulator of the complex
cellular signaling that occurs during all stages of mammalian development. PP2A is …