[HTML][HTML] Mammalian transient receptor potential TRPA1 channels: from structure to disease
K Talavera, JB Startek, J Alvarez-Collazo… - Physiological …, 2020 - journals.physiology.org
The transient receptor potential ankyrin (TRPA) channels are Ca 2+-permeable nonselective
cation channels remarkably conserved through the animal kingdom. Mammals have only …
cation channels remarkably conserved through the animal kingdom. Mammals have only …
Sensory TRP channels in three dimensions
MM Diver, JV Lin King, D Julius… - Annual review of …, 2022 - annualreviews.org
Transient receptor potential (TRP) ion channels are sophisticated signaling machines that
detect a wide variety of environmental and physiological signals. Every cell in the body …
detect a wide variety of environmental and physiological signals. Every cell in the body …
Irritant-evoked activation and calcium modulation of the TRPA1 receptor
The transient receptor potential ion channel TRPA1 is expressed by primary afferent nerve
fibres, in which it functions as a low-threshold sensor for structurally diverse electrophilic …
fibres, in which it functions as a low-threshold sensor for structurally diverse electrophilic …
Structural insights into electrophile irritant sensing by the human TRPA1 channel
Transient receptor potential channel subfamily A member 1 (TRPA1) is a Ca 2+-permeable
cation channel that serves as one of the primary sensors of environmental irritants and …
cation channel that serves as one of the primary sensors of environmental irritants and …
TRPA1: a molecular view
JE Meents, CI Ciotu… - Journal of …, 2019 - journals.physiology.org
The transient receptor potential ankyrin 1 (TRPA1) ion channel is expressed in pain-sensing
neurons and other tissues and has become a major target in the development of novel …
neurons and other tissues and has become a major target in the development of novel …
A cell-penetrating scorpion toxin enables mode-specific modulation of TRPA1 and pain
TRPA1 is a chemosensory ion channel that functions as a sentinel for structurally diverse
electrophilic irritants. Channel activation occurs through an unusual mechanism involving …
electrophilic irritants. Channel activation occurs through an unusual mechanism involving …
Aberrant complement system activation in neurological disorders
K Ziabska, M Ziemka-Nalecz, P Pawelec… - International Journal of …, 2021 - mdpi.com
The complement system is an assembly of proteins that collectively participate in the
functions of the healthy and diseased brain. The complement system plays an important role …
functions of the healthy and diseased brain. The complement system plays an important role …
A novel Flp reporter mouse shows that TRPA1 expression is largely limited to sensory neuron subsets
Transient receptor potential ankyrin 1 (TRPA1) is a polymodal cation channel that is
activated by electrophilic irritants, oxidative stress, cold temperature, and GPCR signaling …
activated by electrophilic irritants, oxidative stress, cold temperature, and GPCR signaling …
[PDF][PDF] Molecular basis of TRPA1 regulation in nociceptive neurons. A review.
A Kádková, V Synytsya, J Krusek, L Zímová… - Physiological …, 2017 - researchgate.net
Transient receptor potential A1 (TRPA1) is an excitatory ion channel that functions as a
cellular sensor, detecting a wide range of proalgesic agents such as environmental irritants …
cellular sensor, detecting a wide range of proalgesic agents such as environmental irritants …
Targeting TRP channels: recent advances in structure, ligand binding, and molecular mechanisms
Transient receptor potential (TRP) channels are a large and diverse family of
transmembrane ion channels that are widely expressed, have important physiological roles …
transmembrane ion channels that are widely expressed, have important physiological roles …