Abstract Phosphatidylinositol 3-kinases (PI3Ks) are crucial coordinators of intracellular
signalling in response to extracellular stimuli. Hyperactivation of PI3K signalling cascades is …

The central role of phosphoinositide 3-kinase (PI3K) activation in tumour cell biology has
prompted a sizeable effort to target PI3K and/or downstream kinases such as AKT and …

The RASopathies are a group of disorders caused by a germline mutation in one of the
genes encoding a component of the RAS/MAPK pathway. These disorders, including …

Abstract Phosphoinositide 3-kinases (PI3Ks) function early in intracellular signal
transduction pathways and affect many biological functions. A further level of complexity …

Phosphoinositide 3-kinases (PI3Ks) control many important aspects of immune cell
development, differentiation, and function. Mammals have eight PI3K catalytic subunits that …

Signalling through the B cell receptor (BCR) is central to the development and maintenance
of B cells. In light of the numerous proliferative and survival pathways activated downstream …

Previous work has shown that mature B cells depend upon survival signals delivered to the
cells by their antigen receptor (BCR). To identify the molecular nature of this survival signal …

The physiology of B cells is intimately connected with the function of their B‐cell receptor
(BCR). B‐cell lymphomas frequently (dys) regulate BCR signalling and thus take advantage …

In germinal centres, somatic hypermutation and B cell selection increase antibody affinity
and specificity for the immunizing antigen, but the generation of autoreactive B cells is an …

Adoptive transfer of T cells that express a chimeric antigen receptor (CAR) is an approved
immunotherapy that may be curative for some hematological cancers. To better understand …