Metalloenzymes are central to a wide range of essential biological activities, including
nucleic acid modification, protein degradation, and many others. The role of metalloenzymes …

Bacterial sepsis is a major cause of fatality worldwide. Sepsis is a multi-step process that
involves an uncontrolled inflammatory response by the host cells that may result in multi …

Clinically significant antibiotic resistance has evolved against virtually every antibiotic
deployed. Yet the development of new classes of antibiotics has lagged far behind our …

Bioterrorism has received a lot of attention in the first decade of this century. Biological
agents are considered attractive weapons for bioterrorism as these are easy to obtain …

Inflammasomes are multiprotein complexes that activate inflammatory cytokines and induce
pyroptosis in response to intracellular danger‐associated signals. NLRP1 and CARD8 are …

Anthrax is caused by the spore-forming, gram-positive bacterium Bacillus anthracis. The
bacterium's major virulence factors are (a) the anthrax toxins and (b) an antiphagocytic …

The functioning of the immune system is finely balanced by the activities of pro-inflammatory
and anti-inflammatory mediators or cytokines. Unregulated activities of these mediators can …

Anthrax toxin consists of three nontoxic proteins that self-assemble at the surface of receptor-
bearing mammalian cells or in solution, yielding a series of toxic complexes. Two of the …

▪ Abstract Anthrax toxin consists of three nontoxic proteins that associate in binary or ternary
combinations to form toxic complexes at the surface of mammalian cells. One of these …

Certain pathogenic species of Bacillus and Clostridium have developed unique methods for
intoxicating cells that employ the classic enzymatic “AB” paradigm for protein toxins. The …