Alzheimer's disease (AD) is a progressive neurodegenerative disease and the most
common cause of dementia. Deposition of amyloid‐β (Aβ) remains a hallmark feature of the …

Signal transduction activator of transcription (STAT) 3 is a member of the STAT protein family
which transduces intracellular and extracellular signals to the nucleus, controlling the …

Quinones can in principle be viewed as a double-edged sword in the treatment of
neurodegenerative diseases, since they are often cytoprotective but can also be cytotoxic …

Alzheimer's disease is one of at least 26 diseases characterized by tau-positive
accumulation in neurons, glia or both. However, it is still unclear what modifications cause …

Several studies have processed conceivable evidence for the vital role of Signal Transducer
and Activator of Transcription 3 (STAT3) in cancer transformation and carcinogenesis …

Cannabinoids, mainly cannabidiol (CBD) and Δ9-tetrahydrocannabinol (THC), are the most
studied group of compounds obtained from Cannabis sativa because of their several …

Alzheimer's disease (AD) is a neurodegenerative disorder with no clear causative event
making the disease difficult to diagnose and treat. The pathological hallmarks of AD include …

Astrocyte reactivity and neuroinflammation are hallmarks of CNS pathological conditions
such as Alzheimer's disease. However, the specific role of reactive astrocytes is still …

Pseudokinases are members of the protein kinase superfamily but signal primarily through
noncatalytic mechanisms. Many pseudokinases contribute to the pathologies of human …

Since the identification of cyclin-dependent kinase-5 (Cdk5) as a tau kinase and member of
the Cdk family almost 20 years ago, deregulation of Cdk5 activity has been linked to an …