New horizons for precision medicine in biliary tract cancers

JW Valle, A Lamarca, L Goyal, J Barriuso, AX Zhu - Cancer discovery, 2017 - AACR
Biliary tract cancers (BTC), including cholangiocarcinoma and gallbladder cancer, are poor-
prognosis and low-incidence cancers, although the incidence of intrahepatic …

Current and emerging therapies for advanced biliary tract cancers

AE Kam, A Masood, RT Shroff - The lancet Gastroenterology & …, 2021 - thelancet.com
Biliary tract cancers (cholangiocarcinomas and gallbladder cancers) are increasing in
incidence and have a poor prognosis. Most patients present with advanced disease, for …

Gemcitabine and oxaliplatin with or without cetuximab in advanced biliary-tract cancer (BINGO): a randomised, open-label, non-comparative phase 2 trial

D Malka, P Cervera, S Foulon, T Trarbach… - The lancet …, 2014 - thelancet.com
Background Gemcitabine plus a platinum-based agent (eg, cisplatin or oxaliplatin) is the
standard of care for advanced biliary cancers. We investigated the addition of cetuximab to …

Evaluation and management of intrahepatic and extrahepatic cholangiocarcinoma

NF Esnaola, JE Meyer, A Karachristos, JL Maranki… - Cancer, 2016 - Wiley Online Library
Cholangiocarcinomas are rare biliary tract tumors that are often challenging to diagnose and
treat. Cholangiocarcinomas are generally categorized as intrahepatic or extrahepatic …

Update on the diagnosis and treatment of cholangiocarcinoma

B Doherty, VE Nambudiri, WC Palmer - Current gastroenterology reports, 2017 - Springer
Abstract Purpose of Review Cholangiocarcinoma is a rare biliary adenocarcinoma
associated with poor outcomes. Cholangiocarcinoma is subdivided into extrahepatic and …

Intrahepatic cholangiocarcinoma: pathogenesis and rationale for molecular therapies

D Sia, V Tovar, A Moeini, JM Llovet - Oncogene, 2013 - nature.com
Intrahepatic cholangiocarcinoma (ICC) is an aggressive malignancy with very poor
prognosis. Genome-wide, high-throughput technologies have made major advances in …

Biliary tract cancers: current knowledge, clinical candidates and future challenges

NA Tariq, MG McNamara, JW Valle - Cancer management and …, 2019 - Taylor & Francis
Biliary tract cancers (BTCs) are rare with poor prognosis. Due to the advent of genomic
sequencing, new data have emerged regarding the molecular makeup of this disease. To …

Intrahepatic cholangiocarcinoma: management options and emerging therapies

RM Dodson, MJ Weiss, D Cosgrove… - Journal of the …, 2013 - journals.lww.com
Intrahepatic cholangiocarcinoma (ICC) is the second most common primary hepatic
malignancy after hepatocellular carcinoma (HCC), accounting for 10% to 15% of primary …

Panitumumab in combination with gemcitabine and oxaliplatin does not prolong survival in wild‐type KRAS advanced biliary tract cancer: A randomized phase 2 trial …

F Leone, D Marino, S Cereda, R Filippi, C Belli… - Cancer, 2016 - Wiley Online Library
BACKGROUND Biliary tract cancer (BTC) is a rare and lethal disease with few therapeutic
options. Preclinical data suggest that the epidermal growth factor receptor (EGFR) pathway …

[HTML][HTML] A KRAS mutation status-stratified randomized phase II trial of gemcitabine and oxaliplatin alone or in combination with cetuximab in advanced biliary tract …

JS Chen, C Hsu, NJ Chiang, CS Tsai, HH Tsou… - Annals of oncology, 2015 - Elsevier
Addition of cetuximab showed trend, but not significantly, to improve the therapeutic effects
of gemcitabine and oxaliplatin combination for advanced biliary tract cancer in current …