The immune-inflammatory response is associated with increased nitro-oxidative stress. The
aim of this mechanistic review is to examine:(a) the role of redox-sensitive transcription …

Solid tumors often grow in a micro-environment characterized by< 2% O 2 tension. This
condition, together with the aberrant activation of specific oncogenic patwhays, increases …

Rationale: Human pluripotent stem cell-derived cardiomyocytes (hPSC-CMs) are a readily
available, robustly reproducible, and physiologically appropriate human cell source for …

Hypoxia is a condition commonly observed in the core of solid tumors. The hypoxia-
inducible factors (HIF) act as hypoxia sensors that orchestrate a coordinated response …

Ferroptosis, a form of regulated cell death, plays an important role in acute kidney injury
(AKI). Previous studies have shown that prolyl hydroxylase domain protein (PHD) inhibitors …

Background & Aims G protein–coupled receptor (GPR) 120 has been implicated in
regulating metabolic syndromes with anti-inflammatory function. However, the role of …

Insufficient oxygen availability (hypoxia) is a precursor to numerous cardiovascular
diseases, including atherosclerosis, pulmonary hypertension, and heart failure. The main …

Given the clinical, economic, and societal impact of obesity, unraveling the mechanisms of
adipose tissue expansion remains of fundamental significance. We previously showed that …

Mitochondria are central organelles in the homeostasis of the cardiovascular system via the
integration of several physiological processes, such as ATP generation via oxidative …

The kidney is a frequent target of autoimmune injury, including in systemic lupus
erythematosus; however, how immune cells adapt to kidney's unique environment and …