Phosphate linkages govern life as we know it. Their unique properties provide the
foundation for many natural systems from cell biology and biosynthesis to the backbone of …

Conspectus Total synthesis—the ultimate proving ground for the invention and field-testing
of new methods, exploration of disruptive strategies, final structure confirmation, and …

Covering: 2016 to 2022 RNA polymerase (RNAP) is the central enzyme in bacterial gene
expression representing an attractive and validated target for antibiotics. Two well-known …

A technically straightforward total synthesis of a new class of vancomycin analogues of
reduced synthetic complexity was developed that provided tetrachlorovancomycin (1, LLS …

A broadly improved second generation catalytic two‐phase strategy for the enantioselective
synthesis of stereogenic at phosphorus (V) compounds is described. This protocol …

An operationally simple, scalable, and chemoselective method for the direct phosphorylation
of alcohols using a P (V)-approach based on the Ψ-reagent platform is disclosed. The …

Covering: 2000 to mid-2021 The phosphate ester is a versatile, widespread functional group
involved in a plethora of biological activities. Its presence in secondary metabolites …

N, O-acetals are part of many synthetic intermediates and important skeletons of numerous
natural products and pharmaceutical drugs. The most straightforward method of the …

Enantioenriched phosphorus (V)-stereogenic compounds, featuring a pentavalent
phosphorus atom as the stereogenic center, are crucial in various natural products, drugs …

A method for the squaramide-organocatalyzed enantioselective addition of a silyl-protected
masked acyl cyanide (MAC) reagent to various β-nitrostyrenes is described. Reactions are …