Despite its very low level in humans, selenium plays an important and unique role among
the (semi) metal trace essential elements because it is the only one for which incorporation …

Brain cancer is regarded among the deadliest forms of cancer worldwide. The distinct tumor
microenvironment and inherent characteristics of brain tumor cells virtually render them …

Free radicals are generated in the brain, as well as in other organs, and their production is
proportional to the brain activity. Due to its low antioxidant capacity, the brain is particularly …

Oxidative stress resulting from excessive free-radical release is likely implicated in the
initiation and progression of epilepsy. Therefore, antioxidant therapies aimed at reducing …

Mitochondrial oxidative stress and dysfunction are contributing factors to various
neurological disorders. Recently, there has been increasing evidence supporting the …

Mitochondrial uncoupling mediated by uncoupling protein 1 (UCP1) is classically associated
with non-shivering thermogenesis by brown fat. Recent evidence indicates that UCP family …

Cocaine is a powerful stimulant of the sympathetic nervous system by inhibiting
catecholamine reuptake, stimulating central sympathetic outflow, and increasing the …

Mitochondrial dysfunction and oxidative stress contribute to several neurologic disorders
and have recently been implicated in acquired epilepsies such as temporal lobe epilepsy …

Sleep deprivation by the disk-over-water technique results in a predictable syndrome of
physiological changes in rats. It has been proposed that reactive oxygen species (ROS) may …

Background Neuroinflammation with activation of microglia and production of
proinflammatory cytokines in the brain plays an active role in epileptic disorders. Brain …