This review summarises current understanding of how bone is sculpted through adaptive
processes, designed to meet the mechanical challenges it faces in everyday life and athletic …

The still‐evolving mechanostat hypothesis for bones inserts tissue‐level realities into the
former knowledge gap between bone's organ‐level and cell‐level realities. It concerns load …

Muscle and bone are closely associated in both anatomy and function, but the mechanisms
that coordinate their synergistic action remain poorly defined. Myostatin, a myokine secreted …

Sarcopenia, the reduction of muscle mass and strength that occurs with aging, is widely
considered one of the major causes of disability in older persons. Surprisingly, criteria that …

The purpose of this multidisciplinary review paper is to critically review evidence from
descriptive, efficacy and effectiveness studies concerned with physical activity and older …

Background: Frailty is a common condition in elders and identifies a state of vulnerability for
adverse health outcomes. Objective: Our objective was to provide a biological face validity to …

Background Sarcopenia, the age-related loss of muscle mass, may not be an isolated
process but is associated with an increase in fat mass. The aim of this study was to estimate …

Sarcopenia is currently considered a geriatric syndrome increasing in older people. The
consequences of sarcopenia–in terms of impaired mobility, limited self-sufficiency and …

Muscle atrophy and bone loss pose substantial problems for long-term space flight and in
clinical immobilization. We therefore tested the efficacy of flywheel resistive exercise and …

The musculoskeletal system evolved in mammals to perform diverse functions that include
locomotion, facilitating breathing, protecting internal organs, and coordinating global energy …