An overview of microneedle applications, materials, and fabrication methods

ZF Rad, PD Prewett, GJ Davies - Beilstein journal of …, 2021 - beilstein-journals.org
Microneedle-based microdevices promise to expand the scope for delivery of vaccines and
therapeutic agents through the skin and withdrawing biofluids for point-of-care diagnostics …

Microneedles for drug and vaccine delivery

YC Kim, JH Park, MR Prausnitz - Advanced drug delivery reviews, 2012 - Elsevier
Microneedles were first conceptualized for drug delivery many decades ago, but only
became the subject of significant research starting in the mid-1990's when microfabrication …

Tutorial on monoclonal antibody pharmacokinetics and its considerations in early development

M Ovacik, K Lin - Clinical and translational science, 2018 - Wiley Online Library
The tutorial introduces the readers to the fundamentals of antibody pharmacokinetics (PK) in
the context of drug development. Topics covered include an overview of antibody …

Pharmacokinetics and pharmacokinetic–pharmacodynamic correlations of therapeutic peptides

L Diao, B Meibohm - Clinical pharmacokinetics, 2013 - Springer
Peptides, defined as polymers of less than 50 amino acids with a molecular weight of less
than 10 kDa, represent a fast-growing class of new therapeutics which has unique …

[图书][B] Handbook of encapsulation and controlled release

M Mishra - 2015 - books.google.com
Written at a level comprehensible to non-experts, this handbook covers the current state of
encapsulation and controlled released technologies, presenting the fundamental processes …

Immunogenicity of biotherapeutics: causes and association with posttranslational modifications

A Kuriakose, N Chirmule, P Nair - Journal of immunology …, 2016 - Wiley Online Library
Today, potential immunogenicity can be better evaluated during the drug development
process, and we have rational approaches to manage the clinical consequences of …

Challenges in delivering therapeutic peptides and proteins: A silk-based solution

J Wu, JK Sahoo, Y Li, Q Xu, DL Kaplan - Journal of Controlled Release, 2022 - Elsevier
Peptide-and protein-based therapeutics have drawn significant attention over the past few
decades for the treatment of infectious diseases, genetic disorders, oncology, and many …

Chitosan nanoparticle-based system: A new insight into the promising controlled release system for lung cancer treatment

C Yee Kuen, MJ Masarudin - Molecules, 2022 - mdpi.com
Lung cancer has been recognized as one of the most often diagnosed and perhaps most
lethal cancer diseases worldwide. Conventional chemotherapy for lung cancer-related …

Therapeutic application of peptides and proteins: parenteral forever?

Z Antosova, M Mackova, V Kral, T Macek - Trends in biotechnology, 2009 - cell.com
Varied therapeutic peptides and proteins represent a rapidly growing part of marketed drugs
and have an undisputed place alongside other established therapies. Nevertheless, such …

Oral protein delivery: Current status and future prospect

K Park, IC Kwon, K Park - Reactive and Functional Polymers, 2011 - Elsevier
Advances in biotechnology have produced therapeutically active proteins on a commercial
scale, and therapeutic proteins are now extensively applied in medical practices to treat …