Discovered as a peptide involved in releasing growth hormone, ghrelin was initially
characterized as the “hunger hormone.” However, emerging research indicates that ghrelin …

Alcohol use disorder (AUD) is a leading cause of morbidity and mortality worldwide.
However, treatment options, including pharmacotherapies, are limited in number and …

Acyl-ghrelin administration increases food intake, body weight, and blood glucose. In
contrast, mice lacking ghrelin or ghrelin receptors (GHSRs) exhibit life-threatening …

Objective The hormone liver-expressed antimicrobial peptide-2 (LEAP2) is a recently
identified antagonist and an inverse agonist of the growth hormone secretagogue receptor …

Ghrelin, a stomach-derived peptide, promotes feeding and growth hormone (GH) secretion.
A recent study identified liver-expressed antimicrobial peptide 2 (LEAP2) as an endogenous …

Much effort has been invested in the investigation of the structural basis of G protein-coupled
receptors (GPCRs) activation. Inverse agonists, which can inhibit GPCRs with constitutive …

Background Growing evidence suggests the key role of ghrelin in the onset and progression
of nonalcoholic fatty liver disease (NAFLD). The potential participation of ghrelin and the …

The membrane is an integral component of the G protein-coupled receptor signaling
machinery. Here we demonstrate that lipids regulate the signaling efficacy and selectivity of …

Data gleaned recently shows that ghrelin, a stomach derived peptide, and liver-expressed-
antimicrobial peptide 2 (LEAP-2) play opposite roles on food intake. However, the data …

Ghrelin and the growth hormone secretagogue receptor 1a (GHS-R1a) are important targets
for disorders related to energy balance and metabolic regulation. Pharmacological control of …