Lysine-specific histone demethylase 1 (LSD1) represents the first example of an identified
nuclear protein with histone demethylase activity. In particular, it plays a special role in the …

The histone acetyltransferases (HATs) of the MYST family are highly conserved in
eukaryotes and carry out a significant proportion of all nuclear acetylation. These enzymes …

Mitogen-activated protein kinase (MAPK) signaling pathways are key mediators of
eukaryotic transcriptional responses to extracellular signals. These pathways control gene …

Summary Background Studies in Drosophila have taught us a great deal about how animals
regulate the immediate innate immune response, but we still know little about how infections …

Summary HBO1, an H4-specific histone acetylase, is a coactivator of the DNA replication
licensing factor Cdt1. HBO1 acetylase activity is required for licensing, because a histone …

Autophagy is an evolutionarily conserved catabolic process through which different
components of the cells are sequestered into double-membrane cytosolic vesicles called …

Old age is associated with a progressive decline of mitochondrial function and changes in
nuclear chromatin. However, little is known about how metabolic activity and epigenetic …

We report here that the MYST histone acetyltransferase HBO1 (h istone acetyltransferase b
ound to O RC; MYST2/KAT7) is essential for postgastrulation mammalian development …

Covalent modifications of histones index structurally and functionally distinct chromatin
domains in eukaryotic nuclei. Drosophila with its polytene chromosomes and developed …

HBO1 histone acetylase is important for DNA replication licensing. In human cells, HBO1
associates with replication origins specifically during the G1 phase of the cell cycle in a …