Histone methylation can occur at various sites in histone proteins, primarily on lysine and
arginine residues, and it can be governed by multiple positive and negative regulators, even …

Transcription factors are involved in a large number of human diseases such as cancers for
which they account for about 20% of all oncogenes identified so far. For long time, with the …

Compelling evidence have demonstrated that bulk tumors can arise from a unique subset of
cells commonly termed “cancer stem cells” that has been proposed to be a strong driving …

Epigenetic dysregulation has emerged as an important mechanism in cancer. Alterations in
epigenetic machinery have become a major focus for targeted therapies. The current report …

The lysine-specific demethylase KDM1A is a key regulator of stem cell potential in acute
myeloid leukemia (AML). ORY-1001 is a highly potent and selective KDM1A inhibitor that …

Lysine-specific histone demethylase 1 (LSD1) represents the first example of an identified
nuclear protein with histone demethylase activity. In particular, it plays a special role in the …

Medical castration that interferes with androgen receptor (AR) function is the principal
treatment for advanced prostate cancer. However, clinical progression is universal, and …

Alterations of genes regulating epigenetic processes are frequently found as cancer drivers
and may cause widespread alterations of DNA methylation, histone modification patterns, or …

Purpose: The addition of immune checkpoint blockade (ICB) to platinum/etoposide
chemotherapy changed the standard of care for small cell lung cancer (SCLC) treatment …

Pharmacologic inhibition of LSD1 promotes blast cell differentiation in acute myeloid
leukemia (AML) with MLL translocations. The assumption has been that differentiation is …