Cellular senescence is a state of terminal cell cycle arrest associated with various
macromolecular changes and a hypersecretory phenotype. In the brain, senescent cells …

Background Maintaining the structural and functional integrity of the blood–brain barrier
(BBB) is vital for neuronal equilibrium and optimal brain function. Disruptions to BBB …

Senescent cells accumulate throughout the body with advanced age, diseases and chronic
conditions. They negatively impact health and function of multiple systems, including the …

Central nervous system (CNS) accumulation of fibrillary deposits made of Amyloid β (A β),
hyperphosphorylated Tau or α-synuclein (α-syn), present either alone or in the form of mixed …

Iron imbalance in the brain negatively affects brain function. With aging, iron levels increase
in the brain and contribute to brain damage and neurological disorders. Changes in the …

Cellular senescence is a cell state characterized by resistance to apoptosis and stable cell
cycle arrest. Senescence was first observed in mitotic cells in vitro. Recent evidence from in …

Advanced technologies have enabled the engineering of self-organized 3-dimensional (3D)
cellular structures from human induced pluripotent stem cells (hiPSCs), namely organoids …

Alzheimer's disease (AD) is a devastating neurodegenerative disease characterized by
abnormal accumulation of tau proteins and amyloid-β, leading to neuronal death and …

Alzheimer's disease (AD) is one of the most common neurodegenerative disorders,
characterized by the accumulation of Aβ and abnormal tau hyperphosphorylation. Despite …

Traumatic brain injury, chronic traumatic encephalopathy, and Alzheimer's disease are three
distinct neurological disorders that share common pathophysiological mechanisms involving …